Por favor, use este identificador para citar o enlazar este ítem:
https://doi.org/10.14670/HH-18-696
Twittear
Registro completo de metadatos
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Zuo, Linwei | - |
dc.contributor.author | You, Huiyan | - |
dc.contributor.author | Cai, Zhe | - |
dc.contributor.author | Liao, Shousheng | - |
dc.contributor.author | Lu, Xiangtong | - |
dc.contributor.author | Li, Lixiang | - |
dc.contributor.author | Huang, Wenyong | - |
dc.date.accessioned | 2024-07-17T10:39:12Z | - |
dc.date.available | 2024-07-17T10:39:12Z | - |
dc.date.issued | 2024 | - |
dc.identifier.citation | Histology and Histopathology, Vol.39, nº8, (2024) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/143154 | - |
dc.description.abstract | Background. Melan-A/MART-1 is a melanocytic differentiation marker recognized as an antigen on melanoma cells. It is a useful diagnostic marker for pathologists in the diagnosis of melanocytic tumors. However, we recently found that Melan-A can be expressed in some non-melanocytic carcinomas that are rarely reported in the literature. Methods. We analyzed the expression of Melan-A in 87 non-melanocytic carcinoma tissue samples by immunohistochemistry. Marker positivity was defined as ≥10% positive tumor cells. Results. In 87 non-melanocytic carcinoma tissue samples, Melan-A was positive in six (6.89%) cases, of which four (66.7%) were male and two (33.3%) were female, with a mean age of 60 years (range 21-82 years). Five (83.3%) of the Melan-A-positive cases had distant metastases. Compared with Melan-A negative cases, Melan-A positive non-melanocytic carcinomas were significantly associated with poor prognosis (P=0.0023). Conclusions. Melan-A expression is relatively rare in non-melanocytic carcinoma cases. This report highlights a potential diagnostic pitfall in the diagnosis of melanoma, urges pathologists to exercise caution in cases of Melan-A positivity, and illustrates the need for an immunohistochemical marker panel to avoid misdiagnosis. | es |
dc.format | application/pdf | es |
dc.format.extent | 5 | es |
dc.language | eng | es |
dc.publisher | Universidad de Murcia. Departamento de Biología Celular e Histología | es |
dc.relation | Sin financiación externa a la Universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Melan-A | es |
dc.subject | Non-melanocytic | es |
dc.subject | Carcinoma | es |
dc.subject | Diagnostic pitfal | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | Melan-A expression in non-melanocytic carcinoma: A potential diagnostic pitfall | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | https://doi.org/10.14670/HH-18-696 | - |
Aparece en las colecciones: | Vol.39, nº8 (2024) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Zuo-39-1037-1041-2024.pdf | 5,96 MB | Adobe PDF | Visualizar/Abrir |
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons