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https://doi.org/10.1111/1348-0421.12447
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Título: | Killer immunoglobulin-like receptor repertoire analysis in a Caucasian Spanish cohort with inflammatory bowel disease |
Fecha de publicación: | nov-2016 |
Editorial: | Wiley |
Cita bibliográfica: | Microbiology and Immunology, 2016, Vol. 60, Issue 11, pp. 787-792 |
ISSN: | Print: 0385-5600 Electronic: 1348-0421 |
Palabras clave: | Crohn disease Inflammatory bowel disease Killer cell immunoglobulin-like receptor polymorphism Ulcerative colitis |
Resumen: | Immunological molecules are implicated in inflammatory disorders, including inflammatory bowel disease (IBD; Crohn disease [CD] and ulcerative colitis [UC]). Killer cell immunoglobulin-like receptors (KIRs) are also genetically variable proteins involved in immune function. They are expressed by NK cells and certain T lymphocytes, regulate specificity and function by interaction with HLA Class I molecules, may be either inhibitory or activating and are polymorphic both in terms of alleles and haplotype gene content. Genetic associations between activating KIRs and certain autoimmune and inflammatory diseases have been reported; however, a possible association between KIR and IBD remains unclear. The aim of this study was to determine the relationship between KIR repertoire and IBD pathologies in a Spanish cohort. KIR variability was analyzed using PCR–sequence specific oligonucleotide probes (SSOP). Inhibitory KIR2DL5 was found more frequently in UC and IBD patient groups than in healthy controls (P = 0.028 and P = 0.01, respectively), as was activating KIR2DS1 (P = 0.02, Pc > 0.05, UC vs. Controls; P = 0.001, Pc = 0.01, IBD vs Controls; P = 0.01, Pc > 0.05, Controls vs CR), KIR2DS5 (P = 0.0028, Pc = 0.04, Controls vs UC; P = 0.0001, Pc = 0.0017, Controls vs IBD; P = 0.01, Pc > 0.05, Controls vs CD) and KIR3DS1 (P = 0.012, Pc > 0.05, Controls vs IBD). Our data suggest that imbalance between activating and inhibitory KIR may partially explain the different pathogeneses of these IBDs and that there is a hypothetical role for the telomeric B region (which contains both KIR2DS5 and KIR2DS1) in these diseases. |
Autor/es principal/es: | López Hernández, Ruth Campillo, Jose Antonio Legaz Pérez, Isabel Valdés, Mariano Salama, Hortensia Boix, Francisco Hernández Martínez, AM Eguia, Jorge González Martínez, G Moya Quiles, María R. Minguela, Alfredo García Alonso, Ana Carballo, Fernando Muro, Manuel |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Ciencias Sociosanitarias |
Versión del editor: | https://onlinelibrary.wiley.com/doi/full/10.1111/1348-0421.12447 |
URI: | http://hdl.handle.net/10201/143055 |
DOI: | https://doi.org/10.1111/1348-0421.12447 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 6 |
Derechos: | info:eu-repo/semantics/embargoedAccess |
Descripción: | © 2016 The Societies and John Wiley & Sons Australia, Ltd. This document is Published version of a Published Work that appeared in final form in Microbiology and Immunology. To access the final edited and published work see https://doi.org/10.1111/1348-0421.12447 |
Aparece en las colecciones: | Artículos: Ciencias Sociosanitarias |
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