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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Legaz Pérez, Isabel | - |
dc.contributor.author | Boix, Francisco | - |
dc.contributor.author | López, Manuela | - |
dc.contributor.author | Alfaro, Rafael | - |
dc.contributor.author | Galián, José A. | - |
dc.contributor.author | Llorente, Santiago | - |
dc.contributor.author | Campillo, José A. | - |
dc.contributor.author | Botella, Carmen | - |
dc.contributor.author | Ramírez, Pablo | - |
dc.contributor.author | Sánchez Bueno, Francisco | - |
dc.contributor.author | Pons, José A. | - |
dc.contributor.author | Moya Quiles, María R. | - |
dc.contributor.author | Minguela, Alfredo | - |
dc.contributor.author | Muro, Manuel | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Ciencias Sociosanitarias | - |
dc.date.accessioned | 2024-07-12T07:44:51Z | - |
dc.date.available | 2024-07-12T07:44:51Z | - |
dc.date.issued | 2020-03-05 | - |
dc.identifier.citation | Journal of Clinical Medicine, 2020, Vol. 9 (3): 708 | es |
dc.identifier.issn | Electronic: 2077-0383 | - |
dc.identifier.uri | http://hdl.handle.net/10201/143039 | - |
dc.description | © 2020 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published version of a Published Work that appeared in final form in Journal of Clinical Medicine. To access the final edited and published work see https://doi.org/10.3390/jcm9030708 | - |
dc.description.abstract | The significance of human leukocyte antigen (HLA) matching and preformed donor-specific antibodies (DSAs) in liver transplantation remains unclear. The aim of this study was to analyze the presence of DSAs in a large cohort of 810 liver recipients undergoing liver transplant to determine the influence on acute (AR) or chronic liver rejection (CR), graft loss and allograft survival. DSAs were identified using complement dependent cytotoxicity crossmatch (CDC-CM) and multiplexed solid-phase-based flow cytometry assay (Luminex). CDC-CM showed that a 3.2% of liver transplants were positive (+CDC-CM) with an AR frequency of 19.2% which was not different from that observed in negative patients (−CDC-CM, 22.3%). Only two patients transplanted with +CDC-CM (7.6%) developed CR and suffered re-transplant. +CDC-CM patients showed a significantly lower survival rate compared to −CDC-CM patients (23.1% vs. 59.1%, p = 0.0003), developing allograft failure within the first three months (p < 0.00001). In conclusion, we have demonstrated a relationship between the presence of preformed DSAs and the low graft liver survival, indicating the important role and the potential interest of performing this analysis before liver transplantation. Our results could help to detect patients with an increased risk of graft loss, a better choice of liver receptors as well as the establishment of individualized immunosuppressive regimens. | es |
dc.format | application/pdf | es |
dc.format.extent | 15 | es |
dc.language | eng | es |
dc.publisher | MDPI | - |
dc.relation | This work was possible thank to support from Instituto de Salud Carlos III (ISCIII), Spanish Ministry of Economy and Competitiveness. Grant Number PI11/02686, PI15/01370 and PI19/01194co-funding of the European Union with European Fund of Regional Development (FEDER) with the principle of “A manner to build Europe”. | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Alcoholic cirrhosis | es |
dc.subject | Crossmatch | es |
dc.subject | Causes of death | es |
dc.subject | Donor specific antibodies | es |
dc.subject | Liver rejection | es |
dc.subject | Forensic medicine | es |
dc.subject | Medico legal autopsy | es |
dc.subject | Survival | es |
dc.title | Influence of preformed antibodies in liver transplantation | es |
dc.type | info:eu-repo/semantics/article | es |
dc.relation.publisherversion | https://www.mdpi.com/2077-0383/9/3/708 | - |
dc.identifier.doi | https://doi.org/10.3390/jcm9030708 | - |
Aparece en las colecciones: | Artículos: Ciencias Sociosanitarias |
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