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https://doi.org/10.1097/TP.0b013e318286486c
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Legaz Pérez, Isabel | - |
dc.contributor.author | López Álvarez, María R. | - |
dc.contributor.author | Campillo, José A. | - |
dc.contributor.author | Moya Quiles, María Rosa | - |
dc.contributor.author | Bolarín, José Miguel | - |
dc.contributor.author | Peña, Jesús de la | - |
dc.contributor.author | Salgado, Gema | - |
dc.contributor.author | Gimeno, Lourdes | - |
dc.contributor.author | García Alonso, Ana M. | - |
dc.contributor.author | Muro, Manuel | - |
dc.contributor.author | Miras, Manuel | - |
dc.contributor.author | Alonso, Clara | - |
dc.contributor.author | Álvarez López, María Rocio | - |
dc.contributor.author | Minguela, Alfredo | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Ciencias Sociosanitarias | - |
dc.date.accessioned | 2024-07-12T08:06:36Z | - |
dc.date.available | 2024-07-12T08:06:36Z | - |
dc.date.issued | 2013-04-27 | - |
dc.identifier.citation | Transplantation Journal 2013;95(8): 1037-1044 | es |
dc.identifier.issn | Print: 0041-1337 | - |
dc.identifier.issn | Electronic: 1534-6080 | - |
dc.identifier.uri | http://hdl.handle.net/10201/143024 | - |
dc.description | © 2013 Lippincott Williams & Wilkins. This document is the Published version of a Published Work that appeared in final form in Transplantation. To access the final edited and published work see https://doi.org/10.1097/TP.0b013e318286486c | - |
dc.description.abstract | Background. Killer immunoglobulin-like receptors (KIRs) bind human leukocyte antigen (HLA) class-I (HLA-I) ligands and regulate functions of natural killer cells and subsets of T cells. KIR/HLA-I interactions allow predicting natural killer cell alloreactivity in hematopoietic stem cell transplantation and in HLA-compatible kidney transplants, but its meaning in liver transplantation remains controversial. Methods. KIR and HLA genotypes were studied in 402 liver transplants, using sequence-specific oligonucleotides and primer methods. Recipients and donor KIRs, HLA-C genotypes, KIR gene mismatches (MMs) between recipient-donor pairs, and KIR/HLA-ligand combinations were analyzed in overall transplantations, in the acute rejection (AR; n=110) and non-AR (n=292) groups. Results. KIR gene MMs between recipients and donors, mainly in activating KIRs, and KIR2DL3 and KIR2DS1 of recipients in the presence of donor C2 ligands, significantly enhanced early AR rate (P<0.05), with KIR2DL3+ and KIR2DS1+ exhibiting a synergic effect in dependence of the donor C2 ligand number (χ2=7.662, P=0.022). KIR2DL3, KIR2DS1, and also KIR2DS4+ significantly influenced short-term graft survival, with a benefit for transplantations combining KIR2DL3+ recipients and donors having C1 ligands (log rank, P<0.019 at 1 year; hazards ratio [HR], 0.321; 95% confidence interval [CI], 0.107–0.962; P=0.042), whereas KIR2DS1+ and KIR2DS4+ recipients combined with donors lacking C1 ligands (C2/C2) exhibited a worse graft survival (log rank, P=0.035 at 6 months; HR, 7.713; 95% CI, 2.156–27.369; P=0.002 for KIR2DS1+; and log rank, P=0.006 at 1 year; HR, 3.794; 95% CI, 1.267–11.365; P=0.017 for KIR2DS4). Conclusions. This study shows that KIR gene-gene MMs increase AR and that KIRs/C ligands associated to AR and KIR2DS4+/C ligands also influence short-term graft survival. | es |
dc.format | application/pdf | es |
dc.format.extent | 8 | es |
dc.language | eng | es |
dc.publisher | Lippincott, Williams & Wilkins | - |
dc.relation | The authors thank the CIBERehd scientific program, funded by the Instituto de Salud Carlos III. | es |
dc.rights | info:eu-repo/semantics/embargoedAccess | es |
dc.subject | KIR | es |
dc.subject | HLA ligands | es |
dc.subject | Liver transplantation | es |
dc.subject | Acute rejection | es |
dc.subject | Short-term graft survival | es |
dc.title | KIR gene mismatching and KIR/C ligands in liver transplantation: consequences for short-term liver allograft injury | es |
dc.type | info:eu-repo/semantics/article | es |
dc.relation.publisherversion | https://journals.lww.com/transplantjournal/Fulltext/2013/04270/KIR_Gene_Mismatching_and_KIR_C_Ligands_in_Liver.9.aspx | - |
dc.embargo.terms | Si | - |
dc.identifier.doi | https://doi.org/10.1097/TP.0b013e318286486c | - |
Aparece en las colecciones: | Artículos: Ciencias Sociosanitarias |
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kir_gene_mismatching_and_kir_c_ligands_in_liver.9.pdf | 396,32 kB | Adobe PDF | ![]() Visualizar/Abrir Solicitar una copia |
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