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Título: | Evaluating the link between BAFF system gene expression and acute rejection development in kidney transplantation |
Fecha de publicación: | 7-jul-2022 |
Editorial: | MDPI |
Cita bibliográfica: | Journal Clinical Medicine 2022, 11(14), 3956 |
ISSN: | Electronic: 2077-0383 |
Palabras clave: | BAFF system Gene expression Kidney transplant Forensic pathology Kidney transplant |
Resumen: | B-cell activating factor (BAFF) system signaling is critical for B-cell homeostasis, effector functions, and tolerance maintenance in transplants, but it has not been studied in kidney transplant recipients (KTRs). The aim was to analyze the changes in BAFF system expression in KTRs with/without acute rejection (AR/NAR). The BAFF system expression was analyzed by qPCR in 40 KTRs. A meta-analysis of BAFF system expression and histological renal damage was identified by the Chronic Allograft Damage Index (CADI) and performed from the GEO database. Proliferation-inducing ligand (APRIL) expression increased at three- and six-months post-KT (p = 0.014 and p < 0.001). B-cell maturation antigen (BCMA) expression increased at six-months post-KT (p = 0.038). BAFF expression remained stable in NAR-KTRs, but was increased in CADI concerning the No-CADI group at one year (p = 0.008). BCMA expression increased in the CADI group at one- (p = 0.001) and six-years post-KT (p = 0.024). At three months, the transmembrane activator and calcium modulator interactor (TACI) gene significantly elevated KTRs with DSAs (donor-specific antibody; p = 0.034). KTRs with DSAs significantly increase the B-cell activating factor receptor (R-BAFF; p = 0.021) and TACI (p = 0.018) between pre- and three-month post-KT. Changes in the expression of the BAFF system increase during post-KTR in the development of AR and chronic allograft damage, and could be an important pathological tool to detect and prevent kidney graft outcomes. |
Autor/es principal/es: | Alfaro, Rafael Llorente, Santiago Jiménez Coll, Víctor Martínez Banaclocha, Helios Galián, José Antonio Botella, Carmen Moya Quiles, María Rosa Muro Pérez, Manuel Peña Moral, Jesús de la Minguela, Alfredo Legaz Pérez, Isabel Muro, Manuel |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas, Departamentos de la UMU::Ciencias Sociosanitarias |
Versión del editor: | https://www.mdpi.com/2077-0383/11/14/3956 |
URI: | http://hdl.handle.net/10201/142932 |
DOI: | https://doi.org/10.3390/jcm11143956 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 17 |
Derechos: | info:eu-repo/semantics/openAccess Atribución 4.0 Internacional |
Descripción: | © 2022 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/. This document is the Published version of a Published Work that appeared in final form in Journal of Clinical Medicine (JCM). To access the final edited and published work see https://doi.org/10.3390/jcm11143956 |
Aparece en las colecciones: | Artículos: Ciencias Sociosanitarias |
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