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Título: | HLA-A*11:01 and HLA-C*04:01 are associated with severe COVID-19 |
Fecha de publicación: | 1-ago-2023 |
Editorial: | John Wiley & Sons |
Cita bibliográfica: | HLA: Immune Response Genetics. 2023; 102(6): 731-739 |
ISSN: | Print: 2059-2302 Electronic: 2059-2310 |
Palabras clave: | COVID-19 HLA evolutionary divergence HLA-A*11:01 HLA-C*04:01 Immunogenetics SARS-CoV-2 |
Resumen: | We analyzed the association between HLA polymorphisms and susceptibility to SARS-CoV-2 infection and disease severity. Genotyping data from a total of 9373 COVID-19-positive cases from the Spanish Coalition to Unlock Research on Host Genetics on COVID-19 (SCOURGE) consortium and 5943 population controls were included in the study. We found an association of the alleles HLA-B*14:02 and HLA-C*08:02 with a lower risk to COVID-19 infection (p = 0.006, OR = 0.84, 95% CI = [0.75–0.95], p = 0.024, OR = 0.86, 95% CI = [0.78–0.95], respectively). We also found the alleles HLA-A*11:01 and HLA- C*04:01 associated with disease severity (p = 0.033, OR = 1.16, 95% CI = [1.04–1.31], p = 0.045, OR = 1.14, 95% CI = [1.05–1.25], respectively). These results suggest that an effective presentation of viral peptides by HLA class I alleles involve a faster infection clearance, decreasing the susceptibility and severity of COVID-19. |
Autor/es principal/es: | Castro-Santos, Patricia Rojas-Martinez, Augusto Riancho, José A. Lapunzina, Pablo Flores, Carlos Carracedo, Angel Díaz-Peña, Roberto García-Vázquez, Elisa Scourge Cohort Group |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Medicina Interna |
Versión del editor: | https://onlinelibrary.wiley.com/doi/10.1111/tan.15160 |
URI: | http://hdl.handle.net/10201/142903 |
DOI: | https://doi.org/10.1111/tan.15160 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 9 |
Derechos: | info:eu-repo/semantics/embargoedAccess |
Descripción: | © 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. This document is the Published, version of a Published Work that appeared in final form in HLA: Immune Response Genetics. To access the final edited and published work see https://doi.org/10.1111/tan.15160 |
Aparece en las colecciones: | Artículos: Medicina |
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HLA are associated with severe COVID‐19.pdf | 1,19 MB | Adobe PDF | Visualizar/Abrir Solicitar una copia |
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