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https://doi.org/10.1128/aac.48.2.670-672.2004
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Título: | Penetration of Linezolid into the Anterior Chamber (Aqueous Humor) of the Human Eye after Intravenous Administration |
Fecha de publicación: | 14-oct-2003 |
Editorial: | American Society for Microbiology |
Cita bibliográfica: | Antimicrobial Agents and Chemotherapy. 2004, 48(2):670-672 |
ISSN: | Print: 0066-4804 Electronic: 1098-6596 |
Resumen: | We determined the linezolid concentrations in serum samples and aqueous humors (AHs) from 21 patients undergoing cataract extraction. Cataract removal was performed at various times (from 60 to 270 min) after the end of a 30-min infusion of 600 mg of linezolid. Serum samples were obtained 1 h after the end of linezolid administration to determine the maximum concentration of linezolid (Cmax ); AHs and a second serum sample were taken simultaneously during the operation, and the concentrations of linezolid in AH (CAH ) and serum (CS ) were determined. The mean CAH 1 h after linezolid administration was 4.94 g/ml, and the mean ratio of CAH to CS (R CAH /CS ) was 0.43. All patients had a CAH of >2 g/ml, which was higher than the MIC at which 90% of Staphylococcus epidermidis strains are inhibited. |
Autor/es principal/es: | García-Vázquez, Elisa Mensa, J. López, Y. Díaz Couchard, P. Soy, D. Fontenla, J. R. Sarasa, M. Carné, X. Montull, E. |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Medicina Interna |
Versión del editor: | https://journals.asm.org/doi/10.1128/aac.48.2.670-672.2004 |
URI: | http://hdl.handle.net/10201/142775 |
DOI: | https://doi.org/10.1128/aac.48.2.670-672.2004 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 3 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Descripción: | ©2004, American Society for Microbiology. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This document is the Published, version of a Published Work that appeared in final form in Antimicrobial Agents and Chemotherapy . To access the final edited and published work see https://doi.org/10.1128/aac.48.2.670-672.2004 |
Aparece en las colecciones: | Artículos: Medicina |
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