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Título: | Penetration of levofloxacin into the anterior chamber (aqueous humour) of the human eye after intravenous administration |
Fecha de publicación: | 11-ene-2007 |
Editorial: | Springer Verlag |
Cita bibliográfica: | European Journal of Clinical Microbiology and Infectious Diseases. (2007) 26(2):137–140 |
ISSN: | Print: 0934-9723 Electronic: 1435-4373 |
Palabras clave: | Levofloxacin Aqueous humour Endophthalmitis Minimum inhibitory concentration Vitreous humour |
Resumen: | In the study presented here, levofloxacin con centrations in serum samples and the aqueous humour (AH) of 16 patients undergoing cataract extraction were measured in order to determine the penetration characteristics of levofloxacin into the AH of the non-inflamed human eye. Cataract removal was performed at various times (from 90 to 270 min) after the end of a 30-min intravenous infusion of 500 mg of levofloxacin. Serum samples were obtained 1 h after the end of levofloxacin administration (C max ); AH and a second serum sample were taken simultaneously during the operation, and the concentrations of levofloxacin in AH (C AH ) and serum (C S) were determined using a rapid high-performance liquid chromatography assay. The mean Cmax was 6.07 μg/ml (range 3.75–9.53 μg/ml, SD 1.83). The mean CAH at the first hour following levofloxacin administration was 1.37 μg/ml (range 1.17–1.6 μg/ml, SD 0.22) and the mean ratio (R=CAH /C S ) was 0.26 (range 0.24–0.3, SD 0.02). The mean CAH at 125–270 min following levofloxacin administration was 1.39 μg/ml (range 0.82–1.98 μg/ml, SD 0.33) and the mean R was 0.3 (range 0.15–0.53, SD 0.11). Of 16 patients, 15 had a CAH of >1 μg/ml 1 h after levofloxacin administration. In conclusion, 1 h after administration of 500 mg of levofloxacin, the levels obtained were higher than the MIC at which 90% of methicillin-susceptible Staphylococcus aureus and certain gram-negative bacteria strains are inhibited. |
Autor/es principal/es: | García-Vázquez, Elisa Mensa, J. Sarasa, M. López, Y. Couchard, P. D. Soy, D. Fontenla, J. R. |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Medicina Interna |
Forma parte de: | The abstract and preliminary results of this study were presented at the 7th European Congress of Chemotherapy and Infection, October 2005, Florence, Italy |
Versión del editor: | https://link.springer.com/article/10.1007/s10096-006-0241-9 |
URI: | http://hdl.handle.net/10201/142770 |
DOI: | https://doi.org/10.1007/s10096-006-0241-9 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 4 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Descripción: | ©Springer-Verlag 2007. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted, version of a Published Work that appeared in final form in European Journal of Clinical Microbiology and Infectious Diseases. To access the final edited and published work see https://doi.org/ 10.1007/s10096-006-0241-9 |
Aparece en las colecciones: | Artículos: Medicina |
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