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Título: | Infective endocarditis in hypertrophic cardiomyopathy: A multicenter, prospective, cohort study |
Fecha de publicación: | 31-may-2016 |
Editorial: | Lippincott, Williams & Wilkins |
Cita bibliográfica: | Medicine. 95(26):e4008, June 2016. |
ISSN: | Print: 0025-7974 Electronic: 1536-5964 |
Palabras clave: | Antibiotic prophylaxis Endocarditis Hypertrophic cardiomyopathy |
Resumen: | Infective endocarditis (IE) complicating hypertrophic cardiomyopathy (HCM) is a poorly known entity. Although current guidelines do not recommend IE antibiotic prophylaxis (IEAP) in HCM, controversy remains. This study sought to describe the clinical course of a large series of IE HCM and to compare IE in HCM patients with IE patients with and without an indication for IEAP. Data from the GAMES IE registry involving 27 Spanish hospitals were analyzed. From January 2008 to December 2013, 2000 consecutive IE patients were prospectively included in the registry. Eleven IE HCM additional cases from before 2008 were also studied. Clinical, microbiological, and echocardiographic characteristics were analyzed in IE HCM patients (n = 34) and in IE HCM reported in literature (n = 84). Patients with nondevice IE (n = 1807) were classified into 3 groups: group 1, HCM with native-valve IE (n = 26); group 2, patients with IEAP indication (n = 696); group 3, patients with no IEAP indication (n = 1085). IE episode and 1-year follow-up data were gathered. One-year mortality in IE HCM was 42% in our study and 22% in the literature. IE was more frequent, although not exclusive, in obstructive HCM (59% and 74%, respectively). Group 1 exhibited more IE predisposing factors than groups 2 and 3 (62% vs 40% vs 50%, P < 0.01), and more previous dental procedures (23% vs 6% vs 8%, P < 0.01). Furthermore, Group 1 experienced a higher incidence of Streptococcus infections than Group 2 (39% vs 22%, P < 0.01) and similar to Group 3 (39% vs 30%, P = 0.34). Overall mortality was similar among groups (42% vs 36% vs 35%, P = 0.64). IE occurs in HCM patients with and without obstruction. Mortality of IE HCM is high but similar to patients with and without IEAP indication. Predisposing factors, previous dental procedures, and streptococcal infection are higher in IE HCM, suggesting that HCM patients could benefit from IEAP. |
Autor/es principal/es: | Dominguez, Fernando Ramos, Antonio Bouza, Emilio Muñoz, Patricia Valerio, Maricela C. Fariñas, M. Carmen Berrazueta, José Ramón de Zarauza, Jesús Pericás Pulido, Juan Manuel Paré, Juan Carlos Alarcón, Arístides de Sousa, Dolores Rodriguez Bailón, Isabel Montejo-Baranda, Miguel Noureddine, Mariam García-Vázquez, Elisa Garcia-Pavia, Pablo |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Medicina Interna |
Versión del editor: | https://journals.lww.com/md-journal/fulltext/2016/06280/infective_endocarditis_in_hypertrophic.40.aspx |
URI: | http://hdl.handle.net/10201/142715 |
DOI: | https://doi.org/10.1097/MD.0000000000004008 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 8 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Descripción: | © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. This manuscript version is made available under the CC BY-SA 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This document is the , Published, version of a Published Work that appeared in final form in Medicine. To access the final edited and published work see https://doi.org/10.1097/MD.0000000000004008 |
Aparece en las colecciones: | Artículos: Medicina |
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