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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Martínez-Esparza, M. | - |
dc.contributor.author | Carmona‐Martínez, Violeta | - |
dc.contributor.author | Ruiz-Alcaraz, Antonio J. | - |
dc.contributor.author | Vera, María | - |
dc.contributor.author | Guirado, Antonio | - |
dc.contributor.author | García-Peñarrubia, Pilar | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Bioquímica y Biología Molecular B e Inmunología | es |
dc.date.accessioned | 2024-06-26T11:53:22Z | - |
dc.date.available | 2024-06-26T11:53:22Z | - |
dc.date.issued | 2018-10-19 | - |
dc.identifier.citation | Medicinal Research Reviews. Mar; 39(2): 461-516 | es |
dc.identifier.issn | Print: 0198-6325 | - |
dc.identifier.issn | Electronic: 1098-1128 | - |
dc.identifier.uri | http://hdl.handle.net/10201/142713 | - |
dc.description | © 2018 Wiley Periodicals, Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This document is the Acepted version of a Published Work that appeared in final form in Medicinal Research Reviews. To access the final edited and published work see https://doi.org/ 10.1002/med.21529 | - |
dc.description.abstract | Pteridines are aromatic compounds formed by fused pyrazine and pyrimidine rings. Many living organisms synthesize pteridines, where they act as pigments, enzymatic cofactors, or immune system activation molecules. This variety of biological functions has motivated the synthesis of a huge number of pteridine derivatives with the aim of studying their therapeutic potential. This review gathers the state‐of‐the‐art of pteridine derivatives, describing their biological activities and molecular targets. The antitumor activity of pteridine‐based compounds is one of the most studied and advanced therapeutic potentials, for which several molecular targets have been identified. Nevertheless, pteridines are also considered as very promising therapeutics for the treatment of chronic inflammation‐related diseases. On the other hand, many pteridine derivatives have been tested for antimicrobial activities but, although some of them resulted to be active in preliminary assays, a deeper research is needed in this area. Moreover, pteridines may be of use in the treatment of many other diseases, such as diabetes, osteoporosis, ischemia, or neurodegeneration, among others. Thus, the diversity of the biological activities shown by these compounds highlights the promising therapeutic use of pteridine derivatives. Indeed, methotrexate, pralatrexate, and triamterene are Food and Drug Administration approved pteridines, while many others are currently under study in clinical trials. | es |
dc.format | application/pdf | es |
dc.format.extent | 56 | es |
dc.language | eng | es |
dc.publisher | Wiley | es |
dc.relation | Violeta Carmona-Martínez's salary has been supported by MINECO (Secretaría de Estado de Investigación, Desarrollo e Innovación, Sistema Nacional de Garantía Juvenil: PEJ-2014-A-95803). We gratefully acknowledge the financial support of the Fundación Séneca of the Comunidad Autónoma de la Región de Murcia (project 19249/PI/14). | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Anti‐inflammatory | es |
dc.subject | Antimicrobial | es |
dc.subject | Cancer | es |
dc.subject | Molecular target | es |
dc.subject | Pteridine | es |
dc.subject | Therapeutic potential | es |
dc.title | Therapeutic potential of pteridine derivatives: a comprehensive review | es |
dc.type | info:eu-repo/semantics/article | es |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/10.1002/med.21529 | es |
dc.identifier.doi | http://doi.org/10.1002/med.21529 | - |
Aparece en las colecciones: | Artículos: Bioquímica y Biología Molecular "B" e Inmunología |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Med Res Rev. 2019 pteridinas.pdf | 2,36 MB | Adobe PDF | Visualizar/Abrir |
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