Por favor, use este identificador para citar o enlazar este ítem:
https://doi.org/10.3390/ijms221910792
![](/digitum/image/email_logo.png)
![](/digitum/image/logo-facebook.png)
Título: | The role of peritoneal macrophages in Endometriosis. |
Fecha de publicación: | 6-oct-2021 |
Editorial: | MDPI |
Cita bibliográfica: | International Journal of Molecular Sciences, 2021, Vol. 22 (19): 10792 |
ISSN: | Print: 1661-6596 Electronic: 1422-0067 |
Palabras clave: | Endometriosis Peritoneal macrophages Inflammation |
Resumen: | Endometriosis is an estrogen-dependent gynecological disorder, defined as the growth of endometrial stromal cells and glands at extrauterine sites. Endometriotic lesions are more frequently located into the abdominal cavity, although they can also be implanted in distant places. Among its etiological factors, the presence of immune dysregulation occupies a prominent place, pointing out the beneficial and harmful outcomes of macrophages in the pathogenesis of this disease. Macrophages are tissue-resident cells that connect innate and adaptive immunity, playing a key role in maintaining local homeostasis in healthy conditions and being critical in the development and sustainment of many inflammatory diseases. Macrophages accumulate in the peritoneal cavity of women with endometriosis, but their ability to clear migrated endometrial fragments seems to be inefficient. Hence, the characteristics of the peritoneal immune system in endometriosis must be further studied to facilitate the search for new diagnostic and therapeutic tools. In this review, we summarize recent relevant advances obtained in both mouse, as the main animal model used to study endometriosis, and human, focusing on peritoneal macrophages obtained from endometriotic patients and healthy donors, under the perspective of its future clinical translation to the role that these cells play on this pathology. |
Autor/es principal/es: | Ramírez Pavez, Tamara N. Martínez Esparza, M. Ruiz Alcaraz, Antonio J. Marín Sánchez, Pilar Machado Linde, Francisco García Peñarrubia, Pilar |
Versión del editor: | https://www.mdpi.com/1422-0067/22/19/10792 |
URI: | http://hdl.handle.net/10201/142712 |
DOI: | https://doi.org/10.3390/ijms221910792 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 19 |
Derechos: | info:eu-repo/semantics/openAccess Atribución 4.0 Internacional |
Descripción: | © 2021 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published version of a Published Work that appeared in final form in International Journal of Molecular Sciences. To access the final edited and published work see https://doi.org/10.3390/ijms221910792 |
Aparece en las colecciones: | Artículos: Bioquímica y Biología Molecular "B" e Inmunología |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
ijms-22-10792-v2.pdf | 1,24 MB | Adobe PDF | ![]() Visualizar/Abrir |
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons