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Título: | Age-related changes in fatty acid profile and locomotor activity rhythms in Nothobranchius korthausae |
Fecha de publicación: | 28-ago-2011 |
Editorial: | Elsevier |
Cita bibliográfica: | Experimental Gerontology, 2011, Vol. 46, N. 12, pp. 970–978 |
ISSN: | Print: 0531-5565 |
Palabras clave: | Nothobranchius korthausae Ageing Fatty acids Locomotor activity Circadian rhythms |
Resumen: | The life cycle of Nothobranchius korthausae, a Cyprinodontiformes fish, was studied in our laboratory to characterise the ageing process. Some morphological changes, such as spine curvature, skin colour, and fin and eye appearance are described. Growth and survival curves reflected a fast life cycle with rapid initial growth until 4 weeks of age, after which the fish grew more slowly before reaching their final size in week 40. Senescence onset was established at week 48 with a decrease in spawn size and viability and a general decline in the animal's appearance (weight and colouration losses, caudal fin degradation, and cataractogenesis). The fatty acid composition changed with age,with high unsaturation in the adult stage as reflected by a high peroxidation index, a condition that is associated with high susceptibility to oxidative damage if elevated reactive oxygen species (ROS) production occurs. Senescent fish had an increase in monounsaturated fatty acid proportions and a lower peroxidation index (226.5±19.7 in adults versus 120.2±19.1 in senescent fish, Pb0.05). The circadian system, as reflected by locomotor activity rhythms, showed noticeable changes with age. Twenty-four-week-old fish (adults) had a robust diurnal rhythm that showed a decrease in total activity, an increase in rhythmfragmentation, and a fall in amplitude and regularity with age. Changes were clearly reflected in the Circadian Function Index variations (0.56, 0.47 and 0.25 at 24, 48 and 72 weeks of age, respectively). In conclusion, N. korthausae appears to be a species with appropriate characteristics for ageing studies because it manifests clear signs of progressive ageing. Comparing species of Nothobranchius genus with different lifespans may be useful for increasing our understanding of the ageing process. |
Autor/es principal/es: | Lucas-Sanchez, A Almaida Pagán, Pedro Francisco Madrid, Juan A Costa, J. de Mendiola, P |
Facultad/Departamentos/Servicios: | Department of Physiology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Fisiología |
Versión del editor: | https://www.sciencedirect.com/science/article/pii/S0531556511002087#aep-acknowledgment-id23 |
URI: | http://hdl.handle.net/10201/142491 |
DOI: | https://doi.org/10.1016/j.exger.2011.08.009 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 9 |
Derechos: | info:eu-repo/semantics/embargoedAccess |
Descripción: | © 2011 Elsevier Inc. This document is the Published version of a Published Work that appeared in final form in Experimental Gerontology. To access the final edited and published work see https://doi.org/10.1016/j.exger.2011.08.009 |
Aparece en las colecciones: | Artículos: Fisiología |
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