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https://doi.org/10.1080/22221751.2022.2098059
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Título: | Effect of oral antiseptics in reducing SARS-CoV-2 infectivity: Evidence from a randomized double- blind clinical trial |
Fecha de publicación: | 27-jul-2022 |
Editorial: | Taylor and Francis Group |
Cita bibliográfica: | Emerging Microbes & Infections. 2022, Vol. 11(1): 1833-1842 |
ISBN: | Electronic: 2222-1751 |
Palabras clave: | SARS-CoV-2 Saliva COVID-19 Infectivity Mouthwas |
Resumen: | Background: In vitro studies have shown that several oral antiseptics have virucidal activity against SARS-CoV-2. Thus, mouthwashes have been proposed as an easy to implement strategy to reduce viral transmission. However, there are no data measuring SARS-CoV-2 viability after mouthwashes in vivo. Methods: In this randomized double-blind, five-parallel-group, placebo-controlled clinical trial, SARS-CoV-2 salivary viral load (by quantitative PCR) and its infectious capacity (incubating saliva in cell cultures) have been evaluated before and after four different antiseptic mouthwashes and placebo in 54 COVID-19 patients. Results: Contrary to in vitro evidence, salivary viral load was not affected by any of the four tested mouthwashes. Viral culture indicated that cetylpyridinium chloride (CPC) significantly reduced viral infectivity, but only at one-hour post-mouthwash. Conclusion: These results indicate that some of the mouthwashes currently used to reduce viral infectivity are not efficient in vivo and, furthermore, that this effect is not immediate, generating a false sense of security. |
Autor/es principal/es: | Sánchez Barrueco, Álvaro Mateos-Moreno, Maria Victoria Martínez- Beneyto, Yolanda García-Vázquez, Elisa Campos González, Alfonso Zapardiel Ferrero, Javier Bogoya Castaño, Abel Alcalá Rueda, Ignacio Villacampa Aubá, José Miguel Cenjor Español, Carlos Moreno-Parrado, Laura Ausina- Márquez, Verónica García-Esteban, Sandra Artacho, Alejandro López- Labrador, F. Xavier Mira, Alex Ferrer, María D. |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Medicina Interna |
Versión del editor: | https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2098059 |
URI: | http://hdl.handle.net/10201/142485 |
DOI: | https://doi.org/10.1080/22221751.2022.2098059 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 23 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Descripción: | ©2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ . This document is the Accepted, version of a Published Work that appeared in final form in Emerging Microbes & Infections. To access the final edited and published work see https://doi.org/10.1080/22221751.2022.2098059 |
Aparece en las colecciones: | Artículos: Medicina |
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