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Título: | Age-related changes in mitochondrial membrane composition of nothobranchius rachovii |
Fecha de publicación: | 17-may-2013 |
Editorial: | Oxford University Press |
Cita bibliográfica: | J Gerontol A Biol Sci Med Sci 2014 February;69(2):142–151 |
ISSN: | Print: 1079-5006 Electronic: 1758-535X |
Palabras clave: | Aging Mitochondria Phospholipid Fatty acid Fish |
Resumen: | Mitochondrial membrane composition may be a critical factor in the mechanisms of the aging process by influencing the propagation of reactions involved in mitochondrial function during periods of high stress. Changes affecting either lipid class or fatty acid compositions could affect phospholipid properties and alter mitochondrial function and cell viability In the present study, mitochondrial membrane phospholipid compositions were analyzed throughout the life cycle of Nothobranchius rachovii. Mitochondrial phospholipids showed several changes with age. Proportions of cardiolipin decreased and those of sphingomyelin increased between 11- and 14-month-old fish. Fatty acid compositions of individual phospholipids in mitochondria were also significantly affected with age. These data suggest increasing damage to mitochondrial lipids during the life cycle of N. rachovii that could be one of the main factors related with and contributing to degraded mitochondrial function associated with the aging process. |
Autor/es principal/es: | Lucas-Sánchez, Alejandro Almaida Pagán, Pedro Francisco Tocher, Douglas R. Mendiola, Pilar Costa, Jorge de |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Fisiología |
Versión del editor: | https://academic.oup.com/biomedgerontology/article/69A/2/142/514518 |
URI: | http://hdl.handle.net/10201/142433 |
DOI: | https://doi.org/10.1093/gerona/glt066 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 10 |
Derechos: | info:eu-repo/semantics/embargoedAccess |
Descripción: | ©The Author 2013. This document is the Published version of a Published Work that appeared in final form in The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences. To access the final edited and published work see https://doi.org/10.1093/gerona/glt066 |
Aparece en las colecciones: | Artículos: Fisiología |
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