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Título: | Post-training scopolamine treatment induced maladaptive behavior in open field habituation task in rats |
Fecha de publicación: | 17-jun-2014 |
Editorial: | Public Library of Science (PLoS) |
Cita bibliográfica: | PLoS One, 2014; Vol. 9, N. 6: e100348 |
ISSN: | Print: 1932-6203 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas |
Palabras clave: | Memory consolidation Open field Scopolamine Rat |
Resumen: | The effects of scopolamine on memory consolidation are controversial and depend on several factors (i.e. site of administration, time of administration and testing, dose, cognitive task, experimental protocol, specie, strain, etc.). Generally, the range dose of systemic administered scopolamine, used in memory consolidation studies, has varied from 0.05 to 50 mg/kg. However, according to the literature, the most frequently used doses of scopolamine efficient on memory consolidation, are 1 and 30 mg/kg, low and high doses, respectively. In open field habituation studies only lower doses of scopolamine were used to test memory consolidation. Therefore, in the present study we compared the effects of low (1 mg/kg) and high (30 mg/kg) scopolamine dose, on the open field habituation task, in male Wistar rats. Scopolamine was administered immediately after the acquisition task and animals were retested 48 h later on. On the retested day, the ambulation and rearing in the open field decreased in the same manner in all tested groups. In saline- and 1 mg/kg scopolamine-treated animals, the time spent in grooming significantly decreased in the habituation task, while the same parameter significantly increased in animals treated with 30 mg/kg of scopolamine. The defecation rate significantly decreased (control group), maintained (1 mg/kg of scopolamine treated animals) or significantly increased (30 mg/kg of scopolamine treated group) on retention test. In conclusion, the present data suggest that post-training scopolamine administration does not affect locomotion neither exploration in the habituation to a novel environment, but increases defecation and grooming, two behaviours associated with fearful and stressful situations. |
Autor/es principal/es: | Popovic, Natalija Caballero Bleda, María Popovic, Miroljub |
Facultad/Departamentos/Servicios: | Facultad de Medicina, Departameno Anatomía y Psicobiología Humana Research Institute of Aging, University of Murcia |
Versión del editor: | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0100348 |
URI: | http://hdl.handle.net/10201/142410 |
DOI: | https://doi.org/10.1371/journal.pone.0100348 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 4 |
Derechos: | info:eu-repo/semantics/openAccess Atribución 4.0 Internacional |
Descripción: | © 2014 Popovic et al. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published version of a Published Work that appeared in final form in PLoS One. To access the final edited and published work see https://doi.org/10.1371/journal.pone.0100348 |
Aparece en las colecciones: | Artículos: Anatomía Humana y Psicobiología |
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