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https://doi.org/10.1016/j.bbalip.2014.04.004
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Título: | Changes in mitochondrial membrane composition and oxidative status during rapid growth, maturation and aging in zebrafish, Danio rerio |
Fecha de publicación: | 24-abr-2014 |
Editorial: | Elsevier |
Cita bibliográfica: | Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids Volume 1841, Issue 7, July 2014, Pages 1003-1011 |
ISSN: | Print: 1388-1981 |
Palabras clave: | Aging Cardiolipin Fatty acid Mitochondrion Danio rerio Oxidative stress |
Resumen: | Considering membranes and membrane components as possible pacemakers of the main processes taking place inside mitochondria, changes in phospholipids or fatty acids could play a central role linking different mechanisms involved in cumulative damage to cell molecules and dysfunction during periods of high stress, such as rapid growth and aging. Changes affecting either lipid class or fatty acid compositions could affect phospholipid and membrane properties and alter mitochondrial function and cell viability. In the present study, mitochondrial oxidative status and mitochondrial membrane phospholipid compositions were analyzed throughout the lifecycle of zebrafish. TBARS content significantly increased in 18-month-old fish while aconitase activity decreased in 24-month-old fish, which have been related with oxidative damage to molecules. Mitochondria-specific superoxide dismutase decreased in 24-month-old animals although this change was not statistically significant. Age affected both mitochondrial phospholipid content and the peroxidation index of most phospholipid classes suggesting that oxidative damage to mitochondrial lipids was occurring. |
Autor/es principal/es: | Almaida Pagán, Pedro Francisco Lucas-Sanchez, A Tocher, D R |
Facultad/Departamentos/Servicios: | Institute of Aquaculture, School of Natural Sciences, University of Stirling, Stirling FK9 4LA, Scotland, United Kingdom Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Fisiología |
Versión del editor: | https://www.sciencedirect.com/science/article/pii/S1388198114000791 |
URI: | http://hdl.handle.net/10201/142392 |
DOI: | https://doi.org/10.1016/j.bbalip.2014.04.004 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 9 |
Derechos: | info:eu-repo/semantics/embargoedAccess |
Descripción: | © 2014 Elsevier B.V This document is the Published version of a Published Work that appeared in final form in Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids. To access the final edited and published work see https://doi.org/10.1016/j.bbalip.2014.04.004 |
Aparece en las colecciones: | Artículos: Fisiología |
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