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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Popovic, Natalija | - |
dc.contributor.author | Baño-Otalora, Beatriz | - |
dc.contributor.author | Rol, María Ángeles | - |
dc.contributor.author | Venero, César | - |
dc.contributor.author | Madrid, Juan Antonio | - |
dc.contributor.author | Popovic, Miroljub | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Anatomía Humana y Psicobiología | es |
dc.date.accessioned | 2024-06-18T10:33:12Z | - |
dc.date.available | 2024-06-18T10:33:12Z | - |
dc.date.issued | 2023-08-03 | - |
dc.identifier.citation | Front. Behav. Neurosci. 2023 17:1221090 | es |
dc.identifier.issn | Electronic: 1662-5153 | - |
dc.identifier.uri | http://hdl.handle.net/10201/142385 | - |
dc.description | ©2023 Popović, Baño-Otalora, Rol, Venero, Madrid and Popović. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/. This document is the Published version of a Published Work that appeared in final form in Frontiers in Behavioral Neuroscience. To access the final edited and published work see https://doi.org/10.3389/fnbeh.2023.1221090 | - |
dc.description.abstract | Prolonged social isolation is a form of passive chronic stress that has consequences on human and animal behavior. The present study was undertaken to elucidate whether the long-term isolation would precipitate age-related changes in anxiety and spatial learning and memory in degus. Methods: We investigated the effects of long-term social isolation on anxiety levels in the light-dark test, and spatial orientation abilities in the Barnes maze. Middle-aged female Octodon degus were allocated to either group-housed (3 animals per cage) or individually-housed for 5 months. Results: Under this experimental condition, there were no significant group differences in the anxiety level tested in the light-dark test and in the motivation to escape from the Barnes maze. There were no significant differences in cortisol levels between individually- and group-housed animals. On the last acquisition training day of spatial learning, individually- housed animals had a significantly higher number of correct responses and a smaller number of reference and working memory errors than the group-housed animals. In addition, isolated animals showed a tendency for reference and working memory impairment on the retention trial, while group-housed degus showed improvement in these parameters. Discussion and conclusion: The present study indicates that prolonged social isolation during adulthood in female degus has a dual effect on spatial orientation. Specifically, it results in a significant improvement in acquisition skills but a slight impairment in memory retention. The obtained cognitive changes were not accompanied by modification in anxiety and cortisol levels. Keywords: Barnes maze; Octodon degus; anxiety; learning and memory; light-dark test; social isolation. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 | es |
dc.language | eng | es |
dc.publisher | Frontiers Media | es |
dc.relation | This research was funded by the Ministry of Economy and Competitiveness, the Instituto de Salud Carlos III through a CIBERFES grant (CB16/10/00239); Diabfrail LatAm (European Union Horizon 2020 research and innovation programme No. 825546) awarded to MR (all co-financed by FEDER); Grant RTI2018-093528-B-I00, funded by MCIN/AEI/10.13039/501100011033; “ERDF A way of making Europe,” by the “European Union NextGenerationEU/PRTR,” and by Spanish Ministry of Science, Innovation, and Universities (PID2021-125945OB-100) awarded to CV. | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Barnes maze | es |
dc.subject | Octodon degus; | es |
dc.subject | Anxiety | es |
dc.subject | Learning and memory | es |
dc.subject | Light-dark test | es |
dc.subject | Social isolation. | es |
dc.subject.other | CDU::6 - Ciencias aplicadas | es |
dc.title | Effects of long-term individual housing of middle-aged female Octodon degus on spatial learning and memory in the Barnes maze task | es |
dc.type | info:eu-repo/semantics/article | es |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fnbeh.2023.1221090/full | es |
dc.identifier.doi | https://doi.org/10.3389/fnbeh.2023.1221090 | - |
Aparece en las colecciones: | Artículos: Anatomía Humana y Psicobiología |
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Popovic et al., Front. Behav. Neurosci. 2023.pdf | 1,16 MB | Adobe PDF | Visualizar/Abrir |
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