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https://doi.org/10.3389/fnana.2021.656882
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Título: | Widespread doublecortin expression in the cerebral cortex of the octodon degus |
Fecha de publicación: | 29-abr-2021 |
Editorial: | Frontiers Media |
Cita bibliográfica: | Frontiers Neuroanatomy April 2021, vol. 15 656882 |
ISSN: | Electronic: 1662-5129 |
Materias relacionadas: | CDU::5 - Ciencias puras y naturales |
Palabras clave: | Octodon degus Cerebral cortex Cortical atlas Doublecortin Limbic system |
Resumen: | It has been demonstrated that in adulthood rodents show newly born neurons in the subgranular layer (SGL) of the dentate gyrus (DG), and in the subventricular zone (SVZ). The neurons generated in the SVZ migrate through the rostral migratory stream (RMS) to the olfactory bulb. One of the markers of newly generated neurons is doublecortin (DCX). The degu similarly shows significant numbers of DCX-labeled neurons in the SGL, SVZ, and RMS. Further, most of the nuclei of these DCX-expressing neurons are also labeled by proliferating nuclear antigen (PCNA) and Ki67. Finally, whereas in rats and mice DCX-labeled neurons are predominantly present in the SGL and SVZ, with only a few DCX neurons present in piriform cortex, the degu also shows significant numbers of DCX expressing neurons in areas outside of SVZ, DG, and PC. Many areas of neocortex in degu demonstrate DCX-labeled neurons in layer II, and most of these neurons are found in the limbic cortices. The DCX-labeled cells do not stain with NeuN, indicating they are immature neurons. |
Autor/es principal/es: | Van Groen, Thomas Kadish, Inga Popovic, Natalija Caballero Bleda, María Baño-Otalora, Beatriz Rol, María Ángeles Madrid, Juan Antonio Popovic, Miroljub |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Anatomía Humana y Psicobiología |
Versión del editor: | https://www.frontiersin.org/articles/10.3389/fnana.2021.656882/full |
URI: | http://hdl.handle.net/10201/142383 |
DOI: | https://doi.org/10.3389/fnana.2021.656882 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 11 |
Derechos: | info:eu-repo/semantics/openAccess Atribución 4.0 Internacional |
Descripción: | © 2021 van Groen, Kadish, Popović, Caballero Bleda, Baño-Otalora, Rol, Madrid and Popović. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/. This document is the Published version of a Published Work that appeared in final form in Frontiers in Neuroanatomy. To access the final edited and published work see https://doi.org/10.3389/fnana.2021.656882 |
Aparece en las colecciones: | Artículos: Anatomía Humana y Psicobiología |
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