Por favor, use este identificador para citar o enlazar este ítem:
https://doi.org/10.1007/s10522-018-9778-0
Twittear
Título: | Age-related changes in mitochondrial membrane composition of Nothobranchius furzeri: comparison with a longer-living Nothobranchius species |
Fecha de publicación: | 9-oct-2018 |
Editorial: | Springer |
Cita bibliográfica: | Biogerontology, 2019, Vol. 20, pp. 83–92 |
ISSN: | Print: 1389-5729 Electronic: 1573-6768 |
Palabras clave: | Biology of aging Mitochondria Fish Lipids |
Resumen: | Membrane compositions, particularly of mitochondria, could be critical factors in the mechanisms of growth and aging, especially during phases of high oxidative stress that result in molecular damage. Changes affecting lipid class or fatty acid (FA) compositions could affect phospholipid (PL) properties and alter mitochondrial function. In the present study, mitochondrial membrane PL compositions were analysed throughout the life-cycle of Nothobranchius furzeri, a species with explosive growth and one of the shortest-lived vertebrates. Mitochondrial PLs showed several changes with age. Proportions of total PLs and PC were reduced while an increase in PS, CL and PE was observed, mainly between the 2.5 and 5 months of fish age, the time during which animals doubled their weight. FA compositions of individual PLs in mitochondria were also significantly affected with age suggesting the existence of increasing damage to mitochondrial lipids during the life-cycle of N. furzeri that could be one of the main contributors to degraded mitochondrial function associated with aging. The peroxidation index values from N. furzeri mitochondrial PLs were significantly lower than those reported in N. rachovii, a species with a two-fold longer life span than N. furzeri, which seems to contradict the membrane pacemaker theory of animal metabolism. |
Autor/es principal/es: | Almaida Pagán, Pedro Francisco Ortega-Sabater, C Lucas-Sanchez, A Gonzalez Silvera, D Martinez-Nicolas, A Rol, M A Mendiola, P Costa, J. de |
Facultad/Departamentos/Servicios: | Chronobiology Lab, Department of Physiology, College of Biology, University of Murcia, Mare Nostrum Campus, IUIE, IMIB-Arrixaca, Murcia, Spain Ciber Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain Department of Cell Biology, College of Biology, University of Murcia, Murcia, Spain Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Fisiología |
Versión del editor: | https://link.springer.com/article/10.1007/s10522-018-9778-0 |
URI: | http://hdl.handle.net/10201/142352 |
DOI: | https://doi.org/10.1007/s10522-018-9778-0 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 10 |
Derechos: | info:eu-repo/semantics/embargoedAccess |
Descripción: | © Springer Nature B.V. 2018. This document is the Published version of a Published Work that appeared in final form in Biogerontology. To access the final edited and published work see https://doi.org/10.1007/s10522-018-9778-0 |
Aparece en las colecciones: | Artículos: Fisiología |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
19. Almaida-Pagan_et_al-2019.pdf | 665,99 kB | Adobe PDF | Visualizar/Abrir Solicitar una copia |
Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.