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https://doi.org/10.14670/HH-18-653
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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Zou, Gaode | - |
dc.contributor.author | Guo, Lian | - |
dc.contributor.author | Shen, Shaochen | - |
dc.contributor.author | Song, Zhen | - |
dc.contributor.author | Ouyang, Zheying | - |
dc.contributor.author | Yu, Yi | - |
dc.date.accessioned | 2024-05-22T07:44:32Z | - |
dc.date.available | 2024-05-22T07:44:32Z | - |
dc.date.issued | 2024 | - |
dc.identifier.citation | Histology and Histopathology Vol. 39, nº6 (2024) | es |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.uri | http://hdl.handle.net/10201/141745 | - |
dc.description.abstract | Objective. The objective of this study was to investigate the involvement of the long non-coding RNA (lncRNA) BRE-AS1 in clear cell renal cell carcinoma (ccRCC) and to explore its potential therapeutic role. Methods. The expression of BRE-AS1 and miR-106b-5p was determined by qRT-PCR. Overexpression of BRE-AS1 and miR-106b-5p were performed to study their relationship. Transwell assays were used to evaluate cell movement. Methylation-specific PCR (MSP) was performed to explore the role of BRE-AS1 in the methylation of the miR-106b-5p gene. Results. The results showed that the expression levels of BRE-AS1 were decreased, while those of miR-106b-5p were increased in ccRCC tissues. BRE-AS1 was found to be closely associated with the prognosis of patients with ccRCC. The expression of BRE-AS1 was inversely correlated with that of miR-106b-5p in tumor tissues. Overexpression of BRE-AS1 led to decreased expression levels of miR-106b-5p and increased methylation of the miR-106b-5p gene, whereas miR-106b-5p did not affect the expression of BRE-AS1. BRE-AS1 inhibited the movement and proliferation of ccRCC cell lines, while miR-106b-5p suppressed the role of BRE-AS1. Conclusion. BRE-AS1 may suppress ccRCC by downregulating the expression of miR-106b-5p. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 | es |
dc.language | eng | es |
dc.publisher | Universidad de Murcia, Departamento de Biologia Celular e Histiologia | es |
dc.relation | Sin financiación externa a la Universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | ccRCC | es |
dc.subject | BRE-AS1 | es |
dc.subject | miR-106b-5p | es |
dc.subject | Survival | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | Long non-coding RNA BRE-AS1 inhibits proliferation, migration and invasion of clear cell renal cell carcinoma by downregulating miR-106b-5p | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | https://doi.org/10.14670/HH-18-653 | - |
Aparece en las colecciones: | Vol.39, nº6 (2024) |
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Zou-39-729-737-2024.pdf | 1,75 MB | Adobe PDF | ![]() Visualizar/Abrir |
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