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Título: | Ir(III) Compounds Containing a Terdentate Ligand Are Potent Inhibitors of Proliferation and Effective Antimetastatic Agents in Aggressive Triple-Negative Breast Cancer Cells |
Fecha de publicación: | 6-jun-2023 |
Editorial: | American Chemical Society |
Cita bibliográfica: | Journal of Medicinal Chemistry 2023, 66, 9766−9783 |
ISSN: | Print: 0022-2623 Electronic: 1520-4804 |
Palabras clave: | Antineoplastic agents Cancer Cells Genetics Transition metals |
Resumen: | Herein, we report a series of new octahedral iridium(III) complexes Ir1–Ir9 of the type [Ir(N^N^N)(C^N)Cl]PF6 (N^N^N = 4′-(p-tolyl)-2,2′:6′,2″-terpyridine; C^N = deprotonated 2-arylbenzimidazole backbone) to introduce new metal-based compounds for effective inhibition of metastatic processes in triple-negative breast cancer (TNBC). The results show that the structural modifications within the C^N scaffold strongly impact the antimetastatic properties of these complexes in TNBC cells. Furthermore, testing the antimetastatic effects of the investigated Ir complexes revealed that the highest antimetastatic activity in TNBC cells is exhibited by complex Ir1. This result was in contrast to the effects of the clinically used drug doxorubicin used in conventional chemotherapy of TNBC, which conversely promoted metastatic properties of TNBC cells. Thus, the latter result suggests that doxorubicin chemotherapy may increase the risk of metastasis of breast cancer cells, so the search for new drugs to treat breast cancer that would show better antitumor effects than doxorubicin is justified. |
Autor/es principal/es: | Cutillas Aullo, Natalia Ruiz López, José Novohradsky, Vojtech Marco Calero, Alicia Markova, Lenka Brabec, Viktor |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Química Inorgánica |
Versión del editor: | https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00586?ref=PDF |
URI: | http://hdl.handle.net/10201/140744 |
DOI: | https://doi.org/10.1021/acs.jmedchem.3c00586 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 18 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional Atribución 4.0 Internacional |
Descripción: | ©2023. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Published, version of a Published Work that appeared in final form in Journal of Medicinal Chemistry. To access the final edited and published work see https://doi.org/10.1021/acs.jmedchem.3c00586 |
Aparece en las colecciones: | Artículos: Química Inorgánica |
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