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https://doi.org/10.1016/j.tiv.2013.11.005
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Hernández-García, A. | - |
dc.contributor.author | Romero, D. | - |
dc.contributor.author | Gómez-Ramírez, P. | - |
dc.contributor.author | María-Mojica, P. | - |
dc.contributor.author | Martínez-López, E. | - |
dc.contributor.author | García-Fernández, A. J. | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Ciencias Sociosanitarias | es |
dc.date.accessioned | 2024-03-08T12:36:41Z | - |
dc.date.available | 2024-03-08T12:36:41Z | - |
dc.date.issued | 2013-11-25 | - |
dc.identifier.citation | Toxicology in Vitro, Vol. 28, N. 2, 2014, pp. 300-306 | es |
dc.identifier.issn | Print: 0887-2333 | - |
dc.identifier.uri | http://hdl.handle.net/10201/140013 | - |
dc.description | ©2013 Elsevier. This document is the Published version of a Published Work that appeared in final form in Toxicology in Vitro. To access the final edited and published work see https://doi.org/10.1016/j.tiv.2013.11.005 | es |
dc.description.abstract | Cadmium and lead are persistent and ubiquitous metals that can cause several deleterious effects in living beings. Apoptosis and necrosis are two types of cell death that can be found after in vivo and in vitro exposure to these metals. In this study, isolated red blood cells from living captive Common buzzard (Buteo buteo) were exposed in vitro to different concentrations of lead, cadmium, and the mixture lead–cadmium in a proportion of 1:10 (similar to that found in previous field studies). Data obtained from dose–response curves were used to evaluate the interactive effects of metal mixtures on cell viability. In general, except for the exposure to NOEC, additivity was the most frequently observed response. As described in human, after in vitro exposure, lead was highly accumulated in buzzard erythrocytes, while cadmium accumulation was scarce. Finally, the type of cell death (apoptosis or necrosis) induced by the exposure to different concentrations of these heavy metals and their mixtures was evaluated in the red blood cells. Apoptosis was found to be the main type of cell death observed after cadmium and/or lead exposure. However, this exposure caused an increase in lysis or necrosis, especially if red blood cells were exposed to high doses. | es |
dc.format | application/pdf | es |
dc.format.extent | 7 | es |
dc.language | eng | es |
dc.publisher | Elsevier | es |
dc.relation | Special thanks to Generalitat Valenciana for permission to obtain the samples. Thanks also to the Ministry for Science and Innovation for their financial support via the NOVEDAR (Consolider-Ingenio 2010), and MASCA’2008 (CGL-2008-4318/BOS) projects. Also thanks to Seneca Foundation of the Autonomous Community of Murica Region (CARM) for the 08758/PI/08 Project. | es |
dc.rights | info:eu-repo/semantics/embargoedAccess | es |
dc.subject | Binary mixtures | es |
dc.subject | Cell death | es |
dc.subject | Common buzzard | es |
dc.subject | Erythrocytes | es |
dc.subject | Apoptosis | es |
dc.subject | Buteo buteo | es |
dc.title | In vitro evaluation of cell death induced by cadmium, lead and their binary mixtures on erythrocytes of Common buzzard (Buteo buteo) | es |
dc.type | info:eu-repo/semantics/article | es |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0887233313003093?via%3Dihub | es |
dc.embargo.terms | SI | - |
dc.identifier.doi | https://doi.org/10.1016/j.tiv.2013.11.005 | - |
Aparece en las colecciones: | Artículos: Ciencias Sociosanitarias |
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