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https://doi.org/10.4049/jimmunol.1600678
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Título: | Tissue Microenvironments in the Nasal Epithelium of Rainbow Trout (Oncorhynchus mykiss) Define Two Distinct CD8a+ Cell Populations and Establish Regional Immunity� |
Fecha de publicación: | 26-oct-2016 |
Editorial: | American Association of Immunologists |
Cita bibliográfica: | The Journal of Immunology (2016) 197 (11): 4453–4463. |
ISSN: | Print ISSN: 0022-1767 Online ISSN: 1550-6606. Online ISSN: 1550-6606. |
Resumen: | Mucosal surfaces require balancing different physiological roles and immune functions. To effectively achieve multifunctionality, mucosal epithelia have evolved unique microenvironments that create unique regional immune responses without impairing other normal physiological functions. Whereas examples of regional immunity are known in other mucosal epithelia, to date, no immune microenvironments have been described in the nasal mucosa, a site where the complex functions of olfaction and immunity need to be orchestrated. In this study we identified the presence of CD8a+ cells in the rainbow trout (Oncorhynchus mykiss) nasal epithelium. Nasal CD8a+ cells display a distinct phenotype suggestive of CD8+ T cells with high integrin b2 expression. Importantly, nasal CD8a+ cells are located in clusters at the mucosal tip of each olfactory lamella but scattered in the neuroepithelial region. The grouping of CD8a+ cells may be explained by the greater expression of CCL19, ICAM-1, and VCAM-1 in the mucosal tip compared with the neuroepithelium. Whereas viral Ag uptake occurred via both tip and lateral routes, tip-resident MHC class II+ cells are located significantly closer to the lumen of the nasal cavity than are their neuroepithelial counterparts, therefore having quicker access to invading pathogens. Our studies reveal compartmentalized mucosal immune responses within the nasal mucosa of a vertebrate species, a strategy that likely optimizes local immune responses while protecting olfactory sensory functions. |
Autor/es principal/es: | Sepahi, Ali Casadei, Elisa Tacchi, Luca Muñoz, Pilar LaPatra, Scott E. Salinas, Irene |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Sanidad Animal |
Versión del editor: | https://journals.aai.org/jimmunol/article/197/11/4453/108933/Tissue-Microenvironments-in-the-Nasal-Epithelium |
URI: | http://hdl.handle.net/10201/139828 |
DOI: | https://doi.org/10.4049/jimmunol.1600678 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 12 |
Derechos: | info:eu-repo/semantics/openAccess |
Descripción: | © 2016 by The American Association of Immunologists, Inc. This document is the published version of a published work that appeared in final form in The Journal of Immunology. To access the final work, see DOI: https://doi.org/10.4049/jimmunol.1600678 |
Aparece en las colecciones: | Artículos: Sanidad Animal |
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Fichero | Descripción | Tamaño | Formato | |
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J Immunol-2016-Sepahi-jimmunol.1600678 (1).pdf | 2,42 MB | Adobe PDF | ![]() Visualizar/Abrir Solicitar una copia |
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