Por favor, use este identificador para citar o enlazar este ítem:
http://dx.doi.org/10.1016/j.math.2014.02.007
Twittear
Título: | Immediate effects of spinal manipulation on nitric oxide, substance Pand pain perception |
Fecha de publicación: | 23-feb-2014 |
Editorial: | Elsevier |
Cita bibliográfica: | Manual Therapy 19 (2014): 411-417 |
ISSN: | 1356-689X |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::614 - Higiene y salud pública. Contaminación. Prevención de accidentes. Enfermería |
Palabras clave: | Spinal manipulation Substance P Nitric oxide Pressure pain threshold |
Resumen: | Previous studies have analyzed the effects of spinal manipulation on pain sensitivity by using severalsensory modalities, but to our knowledge, no studies have focused on serum biomarkers involved in thenociceptive pathway after spinal manipulation. Our objectives were to determine the immediate effect ofcervical and dorsal manipulation over the production of nitric oxide and substance P, and establishingtheir relationship with changes in pressure pain thresholds in asymptomatic subjects. In this single-blindrandomized controlled trial, 30 asymptomatic subjects (16 men) were randomly distributed into 3groups (n¼10 per group): control, cervical and dorsal manipulation groups. Blood samples wereextracted to obtain serum. ELISA assay for substance P and chemiluminescence analysis for nitric oxidedetermination were performed. Pressure pain thresholds were measured with a pressure algometer atthe C5eC6 joint, the lateral epicondyle and the tibialis anterior muscle. Outcome measures were ob-tained before intervention, just after intervention and 2 h after intervention. Our results indicated anincrease in substance P plasma level in the cervical manipulation group (70.55%) when compared withother groups (p<0.05). This group also showed an elevation in the pressure pain threshold at C5eC6(26.75%) and lateral epicondyle level (21.63%) immediately after the intervention (p<0.05). No changesin nitric oxide production were observed. In conclusion, mechanical stimulus provided by cervicalmanipulation increases substance P levels and pressure pain threshold but does not change nitric oxideconcentrations. Part of the hypoalgesic effect of spinal manipulation may be due to the action of sub-stance P. |
Autor/es principal/es: | Molina Ortega, Francisco Lomas Vega, Rafael Hita Contreras, Fidel Plaza Manzano, Gustavo Achalandabaso, Alexander Ramos Morcillo, Antonio Jesús Martínez Amat, Antonio |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Enfermería |
URI: | http://hdl.handle.net/10201/139701 |
DOI: | http://dx.doi.org/10.1016/j.math.2014.02.007 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 7 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Descripción: | ©2014. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted, version of a Published Work that appeared in final form in Manual Therapy. To access the final edited and published work see https://doi.org/10.1016/j.math.2014.02.007 |
Aparece en las colecciones: | Artículos: Enfermería |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
2014 Immediate effects of spinal manipulation on nitric oxide, substance P and pain perception.pdf | 643,56 kB | Adobe PDF | Visualizar/Abrir Solicitar una copia |
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons