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https://doi.org/10.1016/j.rvsc.2021.01.023
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Título: | Untargeted metabolomic profiling of serum in dogs with hypothyroidism |
Fecha de publicación: | 30-ene-2021 |
Editorial: | Elsevier |
ISSN: | Print: 0034-5288 Electronic: 1532-2661 |
Palabras clave: | Hypothyroidism Dogs Metabolomics Endocrine Biomarkers |
Resumen: | Hypothyroidism is one of the most commonly diagnosed endocrine disease in dogs. The clinical signs are caused by a deficiency of the active thyroid hormones triiodothyronine (T3) and thyroxine (T4) and have a negative impact on dog’s quality of life. We hypothesized that serum metabolic profile varies between healthy dogs and dogs with hypothyroidism. Twenty serum samples from dogs with hypothyroidism and 20 from healthy dogs were used for untargeted metabolomics analysis performed by LC/MS analysis. Fifteen metabolites showed significant changes between hypothyroid and healthy dogs, being the pentose phosphate pathway (PPP), aminoacyl-tRNA biosynthesis and pyrimidine metabolism the principal pathways altered in hypothyroidism. Specifically, metabolites such as D-gluconic acid and L-Isoleucine may potentially act as biomarkers of disease. |
Autor/es principal/es: | Muñoz-Prieto, Alberto González-Aróstegui, Luis Rubic, Ivana Cerón, José Joaquín Tvarijonavicite, Asta Horvatic, Anita Mrljak, Vladimir |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Medicina y Cirugía Animal |
URI: | http://hdl.handle.net/10201/139225 |
DOI: | https://doi.org/10.1016/j.rvsc.2021.01.023 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 5 |
Derechos: | info:eu-repo/semantics/embargoedAccess |
Descripción: | © 2021 Elsevier Ltd. All rights reserved. This document is the Published version of a Published Work that appeared in final form in Research in Veterinary Science. To access the final edited and published work see https://doi.org/10.1016/j.rvsc.2021.01.023 |
Aparece en las colecciones: | Artículos: Medicina y Cirugía Animal |
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