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Título: | Brain injections of glial cytoplasmicinclusions induce a multiple systematrophy-like pathology |
Fecha de publicación: | 14-mar-2022 |
Editorial: | Oxford University Pres |
Cita bibliográfica: | Brain n 145, año 2022 |
ISSN: | 1460-2156 0006-8950 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Alpha-synuclein Multiple system atrophy Non-human primates Neurodegeneration |
Resumen: | Synucleinopathies encompass several neurodegenerative diseases, which include Parkinson’s disease, dementiawith Lewy bodies and multiple system atrophy. These diseases are characterized by the deposit ofa-synucleinaggregates in intracellular inclusions in neurons and glial cells. Unlike Parkinson’s disease and dementia withLewy bodies, where aggregates are predominantly neuronal, multiple system atrophy is associated witha-synu-clein cytoplasmic inclusions in oligodendrocytes. Glial cytoplasmic inclusions are the pathological hallmark ofmultiple system atrophy and are associated with neuroinflammation, modest demyelination and, ultimately, neu-rodegeneration.To evaluate the possible pathogenic role of glial cytoplasmic inclusions, we inoculated glial cytoplasmic inclusion-containing brain fractions obtained from multiple system atrophy patients into the striatum of non-human pri-mates. After a 2-yearin vivophase, extensive histochemical and biochemical analyses were performed on thewhole brain.We found loss of both nigral dopamine neurons and striatal medium spiny neurons, as well as loss of oligodendro-cytes in the same regions, which are characteristics of multiple system atrophy. Furthermore, demyelination, neu-roinflammation anda-synuclein pathology were also observed. These results show that thea-synuclein species inmultiple system atrophy-derived glial cytoplasmic inclusions can induce a pathological process in non-human pri-mates, including nigrostriatal and striatofugal neurodegeneration, oligodendroglial cell loss, synucleinopathy andgliosis.The present data pave the way for using this experimental model for MSA research and therapeutic development |
Autor/es principal/es: | Herrero Ezquerro, María Trinidad Margaux, Teil Dovero, Sandra Bourdenx, Mathieu Arotcarena, Marie-Laure Camus, Sandrine Porras, Gregory Thiolat, Marie-Laure Trigo-Damas, Ines Perier, Celine Estrada, Cristina Garcia-Carrillo, Nuria Morari, Michele Meissner, Wassilios G. Vila, Miquel Obeso, Jose A. Bezard, Erwan Dehay, Benjamin |
URI: | http://hdl.handle.net/10201/139202 |
DOI: | https://doi.org/10.1093/brain/awab374 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 16 |
Derechos: | info:eu-repo/semantics/embargoedAccess |
Aparece en las colecciones: | Artículos: Anatomía Humana y Psicobiología |
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