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https://doi.org/10.1016/j.colsurfb.2019.04.030
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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Collado-González, Mar | - |
dc.contributor.author | Pereira, Irina | - |
dc.contributor.author | Pereira-Silva, Miguel | - |
dc.contributor.author | Ferreira, Laura | - |
dc.contributor.author | Caldas, Mariana | - |
dc.contributor.author | Magalhães, Mariana | - |
dc.contributor.author | Figueiras, Ana | - |
dc.contributor.author | Ribeiro, António J. | - |
dc.contributor.author | Veiga, Francisco | - |
dc.contributor.author | Santos, Ana Cláudia | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Biología Celular e Histología | es |
dc.date.accessioned | 2024-02-10T00:15:17Z | - |
dc.date.available | 2024-02-10T00:15:17Z | - |
dc.date.issued | 2019-04-15 | - |
dc.identifier.citation | Colloids and Surfaces B: Biointerfaces 180 (2019) 127–140 | es |
dc.identifier.issn | 1873-4367 | - |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.uri | http://hdl.handle.net/10201/139164 | - |
dc.description | ©2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted version of a Published Work that appeared in final form in Colloids and Surfaces B: Biointerfaces. To access the final edited and published work see https://doi.org/10.1016/j.colsurfb.2019.04.030 | es |
dc.description.abstract | Resveratrol (RES), also known as 3,5,4′-trihydroxystilbene, is a polyphenolic phytoalexin that has been widely researched in the past decade due to its recognized numerous biological activities. Despite the potential benefits of RES, its effective use is limited due to its poor solubility, photosensitivity and rapid metabolism, which strongly undermine RES bioavailability and bioactivity. Thereby, recently, nanotechnology appeared as a po- tential strategy to circumvent RES physicochemical and pharmacokinetics constrains. However, only few studies have addressed the crucial in vivo suitability of the developed delivery systems to improve RES efficacy. Facing this scenario, in the present review, it is intended to present and discuss the in vivo resveratrol bioavailability and bioactivity, following its encapsulation or conjugation in nanotechnology-based carriers, contemplating their pharmacokinetics effectiveness. | es |
dc.format | application/pdf | es |
dc.format.extent | 8 | es |
dc.language | eng | es |
dc.publisher | Elsevier Sci Ltd | es |
dc.relation | This work is funded from Portugal National Funds (FCT/MCTES, Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior) through project UID/QUI/50006/2013, co-financed by European Union (FEDER under the Partnership Agreement PT2020). It was supported as well by the grants FCT PTDC/ CTM-BIO/1518/2014 and FCT PTDC/BTM-MAT/30255/2017 from the Portuguese Foundation for Science and Technology (FCT, Fundação para a Ciência e a Tecnologia) and the European Community Fund (FEDER) through the COMPETE2020 program. The authors wish to acknowledge Fundação para a Ciência e a Tecnologia (FCT), Portuguese Agency for Scientific Research, for financial support through the Research Project POCI-01-0145-FEDER-016642. Irina Pereira ac- knowledges the PhD research grant SFRH/BD/136892/2018 funded by FCT and Programa Operacional Capital Humano (POCH). Laura Ferreira recognizes the PhD grant PD/BDE/142964/2018 attributed by FCT and Laboratórios Basi from Drugs R&D Doctoral Program. Mar Collado-González acknowledges a postdoctoral fellowship (grant no. 20381/PD/17) from Fundación Séneca-Agencia de Ciencia y Tecnología de la Región de Murcia (CARM) | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Resveratrol | es |
dc.subject | Nanotechnology | es |
dc.subject | Nanocarriers | es |
dc.subject | Nanoparticles | es |
dc.subject | Nanoencapsulation | es |
dc.subject | Nanoformulations | es |
dc.subject | Bioavailability | es |
dc.subject | Bioactivity, | es |
dc.subject | In vivo | es |
dc.title | Nanotechnology-based formulations for resveratrol delivery: Effects on resveratrol in vivo bioavailability and bioactivity | es |
dc.type | info:eu-repo/semantics/article | es |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S092777651930253X?via%3Dihub | es |
dc.identifier.doi | https://doi.org/10.1016/j.colsurfb.2019.04.030 | - |
Aparece en las colecciones: | Artículos: Biología Celular e Histología |
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Fichero | Descripción | Tamaño | Formato | |
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CollSurfBBiointerf2019_Santos.pdf | 813,67 kB | Adobe PDF | ![]() Visualizar/Abrir |
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