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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Herrero Ezquerro, María Trinidad | - |
dc.contributor.author | Arotcarena, Marie-Laure | - |
dc.contributor.author | Dovero, Sandra | - |
dc.contributor.author | Prigent, Alice | - |
dc.contributor.author | Bourdenx, Mathieu | - |
dc.contributor.author | Camus, Sandrine | - |
dc.contributor.author | Porras, Gregory | - |
dc.contributor.author | Thiolat, Marie-Laure | - |
dc.contributor.author | Tasselli, Maddalena | - |
dc.contributor.author | Aubert, Philippe | - |
dc.contributor.author | Kruse, Niels | - |
dc.contributor.author | Mollenhauer, Brit | - |
dc.contributor.author | Trigo Damas, Ines | - |
dc.contributor.author | Estrada, Cristina | - |
dc.contributor.author | Garcia-Carrillo, Nuria | - |
dc.contributor.author | Vaikath, Nishant | - |
dc.contributor.author | El-Agnaf, Omar M.A. | - |
dc.contributor.author | Vila, Miquel | - |
dc.contributor.author | Obeso, Jose A. | - |
dc.contributor.author | Derkinderen, Pascal | - |
dc.contributor.author | Dehay, Benjamin | - |
dc.contributor.author | Bezard, Erwan | - |
dc.date.accessioned | 2024-02-09T12:31:28Z | - |
dc.date.available | 2024-02-09T12:31:28Z | - |
dc.date.issued | 2020-05-07 | - |
dc.identifier.citation | Brain Journal of Neurology n.143; año 2020 1462–1475 | es |
dc.identifier.uri | http://hdl.handle.net/10201/139130 | - |
dc.description | ©<2020>. This manuscript version is made available under the CC POR 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Submitted, Accepted, Published, version of a Published Work that appeared in final form in Brain Journal of Neurology . To access the final edited and published work see https://doi:10.1093/brain/awaa096 | es |
dc.description.abstract | In Parkinson’s disease, synucleinopathy is hypothesized to spread from the enteric nervous system, via the vagus nerve, to the CNS. Here, we compare, in baboon monkeys, the pathological consequences of either intrastriatal or enteric injection of a-synucleincontaining Lewy body extracts from patients with Parkinson’s disease. This study shows that patient-derived a-synuclein aggregates are able to induce nigrostriatal lesions and enteric nervous system pathology after either enteric or striatal injection in a non-human primate model. This finding suggests that the progression of a-synuclein pathology might be either caudo-rostral or rostro-caudal, varying between patients and disease subtypes. In addition, we report that a-synuclein pathological lesions were not found in the vagal nerve in our experimental setting. This study does not support the hypothesis of a transmission of a-synuclein pathology through the vagus nerve and the dorsal motor nucleus of the vagus. Instead, our results suggest a possible systemic mechanism in which the general circulation would act as a route for long-distance bidirectional transmission of endogenous a-synuclein between the enteric and the central nervous systems. Taken together, our study provides invaluable primate data exploring the role of the gut-brain axis in the initiation and propagation of Parkinson’s disease pathology and should open the door to the development and testing of new therapeutic approaches aimed at interfering with the development of sporadic Parkinson’s disease. | es |
dc.format | application/pdf | es |
dc.format.extent | 14 | es |
dc.language | eng | es |
dc.publisher | Oxford University Press | es |
dc.relation | The University of Bordeaux and the Centre National de la Recherche Scientifique provided infrastructural support. This work was supported by a grant from the Michael J Fox Foundation (Project Grant No. 2013-8499), Fundacion de Investigacion HM Hospitales (Madrid, Spain), the Fundacio´n Se´neca (Project Grant No: FS19540/PI/14), the TARGET PD ANR grant and The Simone and Cino Del Duca Prize from French Academy of Sciences. M.B. and M.L.A. were supported by grants from Ministe re de l’Enseignement Supe´rieur et de la Recherche fellowship and the France Parkinson Foundation. A.P. and P.D. were supported by grants from CECAP (comite´ d’entente et de coordination des associations de parkinsoniens) and ‘Parkinsoniens de Vende´e’. J.A.O. and I.T.D. were funded by MINECO/AEI/FEDER-UE (SAF2015-67239-P). The help of the Bordeaux Imaging Center, part of the national infrastructure France BioImaging, granted by ANR-10INBS-04-0, is acknowledged. The Human a-Synuclein aggregation TRFRET immunoassay was done in the Biochemistry and Biophysics Platform of the Bordeaux Neurocampus at the Bordeaux University funded by the LABEX BRAIN (ANR- 10-LABX-43) with the help of Y. Rufin. The samples were obtained from the Brain Bank GIE NeuroCEB (BRIF number 0033-00011), funded by the patients’ associations France Alzheimer, France Parkinson, ARSEP, and ‘Connaıˆtre les Syndromes Ce´re´belleux’ to which we express our gratitude. | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Parkinson disease | es |
dc.subject | a-synuclein | es |
dc.subject | Neurodegeneration | es |
dc.subject | gut | es |
dc.subject | Monkey | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
dc.title | Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates | es |
dc.type | info:eu-repo/semantics/article | es |
dc.relation.publisherversion | https://academic.oup.com/brain/article/143/5/1462/5831949?login=true | es |
dc.identifier.doi | http//:doi:10.1093/brain/awaa096 | - |
Aparece en las colecciones: | Artículos: Anatomía Humana y Psicobiología |
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2020 Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates.pdf | 1,7 MB | Adobe PDF | Visualizar/Abrir |
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