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https://doi.org/10.1016/j.bbr.2019.112066
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Estrada, Cristina | - |
dc.contributor.author | Cuenca, Lorena | - |
dc.contributor.author | Cano Fernández, Lorena | - |
dc.contributor.author | Gil Martinez, Ana Luisa | - |
dc.contributor.author | Sánchez Rodrigo, Consuelo | - |
dc.contributor.author | González Cuello, Ana Maria | - |
dc.contributor.author | Fernández Villalba, Emiliano | - |
dc.contributor.author | Herrero, Maria Teresa | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Enfermería | - |
dc.date.accessioned | 2024-02-09T09:33:23Z | - |
dc.date.available | 2024-02-09T09:33:23Z | - |
dc.date.created | 2019-06 | - |
dc.identifier.uri | http://hdl.handle.net/10201/139071 | - |
dc.description | ©2019. This document is the Published version of a Published Work that appeared in final form in Behavioural Brain Research. To access the final edited and published work see https://doi.org/10.1016/j.bbr.2019.112066 | - |
dc.description.abstract | Sleep deprivation (SD) has been reported to induce transient cognitive impairment in functional domains commonly affected in dementia, including memory. Indeed, sleep disturbance has been proposed as an early marker for Alzheimer’s disease (AD). SD emulates many aging-related modifications, including important memory dysfunctions possibly caused by triggers of stress such as cortisol. Although exercise is widely assumed to be beneficial for overall health, only recently has the research community focused its attention on its possible effects on brain functions such as cognition. Octodon degus (O. degus) is a recent rodent model considered suitable for the study of neurodegenerative diseases, since it spontaneously develops several histopathological hallmarks observed in AD. We aimed to uncover the interaction between stress, exercise, age and transient memory impairments after SD insult. In this study, animals had free individual access to wheels to practice voluntary exercise. The Barnes Maze (BM) task was conducted with young and aged O. degus animals after combining voluntary exercise and either normal sleep or SD. Plasma cortisol levels were measured after each condition. SD impaired hippocampus-dependent memory in both young and old animals, while cortisol levels did not significantly differ between non-SD and SD animals. However, voluntary exercise for 45 days improved the cognitive impairment caused by SD compared with the control condition. Moreover, voluntary exercise decreased plasma cortisol levels in both conditions, independently of the age. | es |
dc.format | application/pdf | es |
dc.format.extent | 6 | es |
dc.language | eng | es |
dc.publisher | Elsevier | es |
dc.relation | This work was supported by grants from the Spanish Ministry of Science and Innovation (FIS PI13 01293; ISCIII Plan Estatal I+D+i 2013–2016), Fundación Séneca (FS/19540/PI/14), and “Prediction of cognitive properties of new drug candidates for neurodegenerative diseases in early clinical development” (European Community’s Seventh Framework Program, FP7/2007-2013, for the Innovative Medicine Initiative under Grant Agreement No 115009) and IMIB (Biomedical Research Institute of Murcia) to MTH. | es |
dc.rights | info:eu-repo/semantics/embargoedAccess | es |
dc.subject | Alzheimer’s disease | es |
dc.subject | Voluntary exercise | es |
dc.subject | Memory | es |
dc.subject | Cortisol | es |
dc.subject | Sleep | es |
dc.title | Voluntary exercise reduces plasma cortisol levels and improves transitory memory impairment in young and aged Octodon degus | es |
dc.type | info:eu-repo/semantics/article | es |
dc.embargo.terms | Si | - |
dc.identifier.doi | https://doi.org/10.1016/j.bbr.2019.112066 | - |
Aparece en las colecciones: | Artículos: Enfermería |
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2019_Voluntary exercise reduces plasma cortisol levels.pdf | Voluntary exercise reduces plasma cortisol levels. | 563,39 kB | Adobe PDF | ![]() Visualizar/Abrir Solicitar una copia |
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