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Título: | A New Tool to Study Parkinsonism in the Context of Aging: MPTP Intoxication in a Natural Model of Multimorbidity |
Fecha de defensa / creación: | abr-2021 |
Editorial: | MDPI |
ISSN: | Print: 1661-6596 Electronic: 1422-0067 |
Palabras clave: | Ageing Parkinson’s disease Neurodegeneration |
Resumen: | The diurnal rodent Octodon degus (O. degus) is considered an attractive natural model for Alzheimer’s disease and other human age-related features. However, it has not been explored so far if the O. degus could be used as a model to study Parkinson’s disease. To test this idea, 10 adult male O. degus were divided into control group and MPTP-intoxicated animals. Motor condition and cognition were examined. Dopaminergic degeneration was studied in the ventral mesencephalon and in the striatum. Neuroinflammation was also evaluated in the ventral mesencephalon, in the striatum and in the dorsal hippocampus. MPTP animals showed significant alterations in motor activity and in visuospatial memory. Postmortem analysis revealed a significant decrease in the number of dopaminergic neurons in the ventral mesencephalon of MPTP animals, although no differences were found in their striatal terminals. We observed a significant increase in neuroinflammatory responses in the mesencephalon, in the striatum and in the hippocampus of MPTP-intoxicated animals. Additionally, changes in the subcellular expression of the calcium-binding protein S100 were found in the astrocytes in the nigrostriatal pathway. These findings prove for the first time that O. degus are sensitive to MPTP intoxication and, therefore, is a suitable model for experimental Parkinsonism in the context of aging. |
Autor/es principal/es: | Cuenca, Lorena Pizzichini, Elisa Gonçalves, Valeria C. Guillén Díaz, María Aguilar Moñino, Elena Sánchez Rodrigo, Consuelo González Cuello, Ana María Fernández Villalba, Emiliano Herrero, María Trinidad |
URI: | http://hdl.handle.net/10201/139068 |
DOI: | https://doi.org/ 10.3390/ijms22094341 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 19 |
Derechos: | info:eu-repo/semantics/openAccess Atribución 4.0 Internacional |
Descripción: | ©2021. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the Published version of a Published Work that appeared in final form in International Journal of Molecular Sciences. To access the final edited and published work see https://doi.org/ 10.3390/ijms22094341 |
Aparece en las colecciones: | Artículos: Enfermería |
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2021_A New Tool to Study Parkinsonism in the Context of Aging.pdf | Parkinsonism in the Context of Aging | 5,4 MB | Adobe PDF | Visualizar/Abrir |
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