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https://doi.org/10.1016/j.neuro.2018.01.004
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Título: | Electrical stimulation or MK-801 in the inferior colliculus improve motor deficits in MPTP-treated mice |
Fecha de publicación: | ene-2018 |
Editorial: | Elsevier. Science Direct |
Cita bibliográfica: | NeuroToxicology 65 (2018) 38–43 |
ISSN: | 0161-813X |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina CDU::6 - Ciencias aplicadas::61 - Medicina::611 - Anatomía CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.8 - Neurología. Neuropatología. Sistema nervioso |
Palabras clave: | Deep brain stimulation Parkinson’s disease MPTP MPTP |
Resumen: | The inferior colliculus (IC) is an important midbrain relay station for the integration of descending and ascending auditory information. Additionally, the IC has been implicated in processing sensorimotor responses. Glutamatergic and GABAergic manipulations in the IC can improve motor deficits as demonstrated by the animal model of haloperidol-induced catalepsy. However, how the IC influences motor function remains unclear. We investigated the effects of either intracollicular deep brain stimulation (DBS) or microinjection of the glutamatergic antagonist MK-801 or the agonist NMDA in C57BL/6J mice chronically treated with saline or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). After DBS or microinjections, the mice were submitted to rotarod and open field tests, respectively. DBS in the IC was effective to increase the time spent on the rotarod in MPTP-treated mice. After unilateral microinjection of MK-801, but not NMDA, MPTP-treated mice increased the distance travelled in the open field (p < 0.05). In conclusion, intracollicular DBS or MK-801 microinjection can improve motor performance in parkinsonian mice suggesting the IC as a new and non-conventional therapeutic target in motor impairment. |
Autor/es principal/es: | Melo Thomas, L Gil-Martinez, AL Cuenca, L Estrada, C Gonzalez-Cuello, A Schwarting, RK Herrero, MT |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Enfermería |
Versión del editor: | https://www.sciencedirect.com/science/article/pii/S0161813X18300238?via%3Dihub |
URI: | http://hdl.handle.net/10201/139066 |
DOI: | https://doi.org/10.1016/j.neuro.2018.01.004 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 6 |
Derechos: | info:eu-repo/semantics/embargoedAccess |
Aparece en las colecciones: | Artículos: Enfermería |
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Fichero | Descripción | Tamaño | Formato | |
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2018_Electrical stimulation or MK-801.pdf | 1,66 MB | Adobe PDF | Visualizar/Abrir Solicitar una copia |
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