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https://doi.org/10.1016/j.arr.2020.101204
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Cuenca Bermejo, Lorena | - |
dc.contributor.author | Pizzichini, Elisa | - |
dc.contributor.author | González Cuello, Ana María | - |
dc.contributor.author | De Stefano, María Egle | - |
dc.contributor.author | Fernández Villalba, Emiliano | - |
dc.contributor.author | Herrero, María Trinidad | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Enfermería | es |
dc.date.accessioned | 2024-02-09T09:16:37Z | - |
dc.date.available | 2024-02-09T09:16:37Z | - |
dc.date.issued | 2020-12 | - |
dc.identifier.uri | http://hdl.handle.net/10201/139064 | - |
dc.description.abstract | Integrating the multifactorial processes co-occurring in both physiological and pathological human conditions still remains one of the main challenges in translational investigation. Moreover, the impact of age-associated disorders has increased, which underlines the urgent need to find a feasible model that could help in the development of successful therapies. In this sense, the Octodon degus has been indicated as a 'natural' model in many biomedical areas, especially in ageing. This rodent shows complex social interactions and high sensitiveness to early-stressful events, which have been used to investigate neurodevelopmental processes. Interestingly, a high genetic similarity with some key proteins implicated in human diseases, such as apolipoprotein-E, β-amyloid or insulin, has been demonstrated. On the other hand, the fact that this animal is diurnal has provided important contribution in the field of circadian biology. Concerning age-related diseases, this rodent could be a good model of multimorbidity since it naturally develops cognitive decline, neurodegenerative histopathological hallmarks, visual degeneration, type II diabetes, endocrinological and metabolic dysfunctions, neoplasias and kidneys alterations. In this review we have collected and summarized the studies performed on the Octodon degus through the years that support its use as a model for biomedical research, with a special focus on ageing. | es |
dc.format | application/pdf | es |
dc.format.extent | 18 | es |
dc.language | eng | es |
dc.publisher | Elsevier. Science Direct | es |
dc.relation | This research was supported by Fundaci´on S´eneca (19540/PI/14). LCB is granted by the Spanish Ministry of Science, Innovation and Universities (FPU 18/02549), and PE by the “Torno Subito”, Programme promoted by the Regione Lazio and managed by DiSCo Lazio (1912116092019). | es |
dc.rights | info:eu-repo/semantics/embargoedAccess | es |
dc.subject | Ageing | es |
dc.subject | Neurosciences | es |
dc.subject | Multimorbidity | es |
dc.subject | Biomedicine | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::614 - Higiene y salud pública. Contaminación. Prevención de accidentes. Enfermería | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::615 - Farmacología. Terapéutica. Toxicología. Radiología | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.8 - Neurología. Neuropatología. Sistema nervioso | es |
dc.title | Octodon degus: a natural model of multimorbidity for ageing research | es |
dc.type | info:eu-repo/semantics/article | es |
dc.embargo.terms | Si | - |
dc.embargo.terms | Si | - |
dc.identifier.doi | https://doi.org/10.1016/j.arr.2020.101204 | - |
Aparece en las colecciones: | Artículos: Enfermería |
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2020_Octodon degus- a natural model of multimorbidity for ageing research.pdf | 6,08 MB | Adobe PDF | Visualizar/Abrir Solicitar una copia |
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