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https://doi.org/10.3390/ijms23126738
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | López Martínez, María José | - |
dc.contributor.author | Cerón, José J. | - |
dc.contributor.author | Ortin Bustillo, Alba | - |
dc.contributor.author | Escribano, Damián | - |
dc.contributor.author | Kuleš, Josipa | - |
dc.contributor.author | Beletić, Anđelo | - |
dc.contributor.author | Rubić, Ivana | - |
dc.contributor.author | González Sánchez, Juan Carlos | - |
dc.contributor.author | Mrljak, Vladimir | - |
dc.contributor.author | Martínez Subiela, Silvia | - |
dc.contributor.author | Muñoz Prieto, Alberto | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU:: Medicina y Cirugía Animal | - |
dc.date.accessioned | 2024-02-09T09:37:24Z | - |
dc.date.available | 2024-02-09T09:37:24Z | - |
dc.date.issued | 2022-06-16 | - |
dc.identifier.citation | International Journal of Molecular Sciences 23 ( 2022): 6738 | es |
dc.identifier.issn | Print: 1661-6596 | - |
dc.identifier.issn | Electronic: 1422-0067 | - |
dc.identifier.uri | http://hdl.handle.net/10201/139032 | - |
dc.description | ©2022. This manuscript version is made available under the CC-BY4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Published, version of a Published Work that appeared in final form in International Journal of Molecular Sciences. To access the final edited and published work see https://doi.org/10.3390/ijms23126738 | - |
dc.description.abstract | Sepsis is a systemic inflammatory response triggered by an infectious agent and is recognized by the World Health Organization as a global concern, since it is one of the major causes of severe illness in humans and animals. The study of the changes that can occur in saliva and serum in sepsis can contribute to a better understanding of the pathophysiological mechanisms involved in the process and also to discover potential biomarkers that can help in its diagnosis and monitoring. The objective of this study was to characterize the changes that occur in the salivary and serum proteome of pigs with experimentally-induced sepsis. The study included five pigs with sepsis induced by LPS administration and five pigs with non-septic inflammation induced by turpentine for comparative purposes. In saliva, there were eighteen salivary proteins differentially expressed in the sepsis condition and nine in non-septic inflammation. Among these, significant increments in aldolase A and serpin B12 only occurred in the sepsis model. Changes in aldolase A were validated in a larger population of pigs with sepsis due to Streptococcus suis infection. In serum, there were 30 proteins differentially expressed in sepsis group and 26 proteins in the non-septic group, and most of the proteins that changed in both groups were related to non-specific inflammation. In the saliva of the septic animals there were some specific pathways activated, such as the organonitrogen compound metabolic process and lipid transport, whereas, in the serum, one of the main activated pathways was the regulation of protein secretion. Overall, saliva and serum showed different proteome variations in response to septic inflammation and could provide complementary information about the pathophysiological mechanisms occurring in this condition. Additionally, salivary aldolase A could be a potential biomarker of sepsis in pigs that should be confirmed in a larger population | es |
dc.format | application/pdf | es |
dc.format.extent | 16 | - |
dc.language | eng | es |
dc.publisher | MDPI | - |
dc.relation | MCIN/AEI/10.13039/501100011033, grant number PID2019-105950RB-100 and the European Structural and Investment Funds (Grant Agreement KK.01.1.16.0004) | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Pigs | es |
dc.subject | Proteomics | es |
dc.subject | Saliva | es |
dc.subject | Sepsis | es |
dc.subject | Serum | es |
dc.title | A Proteomic Approach to Elucidate the Changes in Saliva and Serum Proteins of Pigs with Septic and Non-Septic Inflammation | es |
dc.type | info:eu-repo/semantics/article | es |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/23/12/6738 | es |
dc.identifier.doi | https://doi.org/10.3390/ijms23126738 | - |
Aparece en las colecciones: | Artículos: Medicina y Cirugía Animal |
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ijms-23-06738-v2-1.pdf | 2,9 MB | Adobe PDF | ![]() Visualizar/Abrir |
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