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https://doi.org/10.3390/ijerph19010041
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Título: | Salivary Ferritin Changes in Patients with COVID-19 |
Fecha de publicación: | 21-dic-2021 |
Editorial: | MDPI |
Cita bibliográfica: | International Journal of Environmental Research and Public Health 2022, 19(1), 41 |
ISSN: | Electronic: 1660-4601 Print: 1661-7827 |
Palabras clave: | COVID-19 Ferritin Non-invasive sample Biomarker |
Resumen: | High ferritin serum levels can be found in patients with macrophage activation syndrome, and increased serum ferritin due to cytokine storm have been reported in severe COVID-19 patients. Saliva is being increasingly used in COVID-19 tests as a diagnostic sample for virus detection and quantification. This study aimed to evaluate the possible changes in ferritin in saliva in COVID-19 patients. In addition, the effects of different inactivation SARS-CoV-2 treatments in ferritin measurements in saliva, the correlation between ferritin in saliva and serum, and the possible effects of correction of ferritin values by total protein were assessed. Ferritin was measured in saliva from healthy (n = 30) and COVID-19 (n = 65) patients with severe, (n = 18) or mild (n = 47) disease, depending on the need for nasal flow oxygen or assisted respiration. Ferritin was also measured in paired serum and saliva samples (n = 32) from healthy and COVID-19 patients. The evaluated inactivation protocols did not affect the assay’s results except the addition of 0.5% SDS. Significantly higher ferritin was found in the saliva of COVID-19 patients (median; 25–75th percentile) (27.75; 9.77–52.2 µg/L), compared with healthy controls (4.21; 2.6–8.08 µg/L). Individuals with severe COVID-19 showed higher ferritin values in saliva (48.7; 18.7–53.9) than mild ones (15.5; 5.28–41.3 µg/L). Significant correlation (r = 0.425; p < 0.001) was found between serum and saliva in ferritin. Ferritin levels were higher in COVID-19 patients in serum and saliva, and the highest values were found in those patients presenting severe symptomatology. In conclusion, ferritin in saliva has the potential to be a biomarker to evaluate severity in patients with COVID-19. |
Autor/es principal/es: | Franco Martínez, Lorena Cerón, José J. Vicente Romero, Maria R. Bernal, Enrique Torres Cantero, Alberto Tecles, Fernando Sánchez Resalt, Cristina Martínez, Mónica Tvarijonaviciute, Asta Martínez Subiela, Silvia |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Medicina y Cirugía Animal |
Versión del editor: | https://www.mdpi.com/1660-4601/19/1/41 |
URI: | http://hdl.handle.net/10201/138884 |
DOI: | https://doi.org/10.3390/ijerph19010041 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 9 |
Derechos: | info:eu-repo/semantics/embargoedAccess |
Descripción: | ©2021. This document is the Published, version of a Published Work that appeared in final form in International Journal of Environmental Research and Public Health. To access the final edited and published work see https://doi.org/10.3390/ijerph19010041 |
Aparece en las colecciones: | Artículos: Medicina y Cirugía Animal |
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Fichero | Descripción | Tamaño | Formato | |
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ijerph-19-00041-v2.pdf | 799,36 kB | Adobe PDF | ![]() Visualizar/Abrir Solicitar una copia |
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