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https://doi.org/10.1038/sj.embor.7400667
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Título: | Increased p53 activity does not accelerate telomere-driven ageing |
Fecha de publicación: | may-2006 |
Editorial: | EMBO Report |
ISSN: | Print: 1469-221X Electrónico: 1469-3178 |
Materias relacionadas: | CDU::5 - Ciencias puras y naturales::57 - Ciencias biológicas en general:577 - 577 Bioquímica. Biología molecular. Biofísica |
Resumen: | There is a great interest in determining the impact of p53 on ageing and, for this, it is important to discriminate among the known causes of ageing. Telomere loss is a well-established source of age-associated damage, which by itself can recapitulate ageing in mouse models. Here, we have used a genetic approach to interrogate whether p53 contributes to the elimination of telomere-damaged cells and its impact on telomere-driven ageing. We have generated compound mice carrying three functional copies of the p53 gene (super-p53) in a telomerase-deficient background and we have measured the presence of chromosomal abnormalities and DNA damage in several tissues. We have found that the in vivo load of telomere-derived chromosomal damage is significantly decreased in super-p53/telomerase-null mice compared with normal-p53/telomerase-null mice. Interestingly, the presence of extra p53 activity neither accelerates nor delays telomere-driven ageing. From these observations, we conclude that p53 has an active role in eliminating telomere-damaged cells, and we exclude the possibility of an age-promoting effect of p53 on telomere-driven ageing. |
Autor/es principal/es: | García-Cao, Isabel García-Cao, Marta Tomas-Loba, Antonia Martin-Caballero, Juan Flores, Juana M Klatt, Peter Blasco, Maria Antonia Serrano, Manuel |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Departamento de Fisiología |
URI: | http://hdl.handle.net/10201/138805 |
DOI: | https://doi.org/10.1038/sj.embor.7400667 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 7 |
Derechos: | info:eu-repo/semantics/embargoAccess |
Descripción: | Item en revisión. Pendiente de cumplimentar metadatos. Con embargo |
Aparece en las colecciones: | Artículos: Fisiología |
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garcía-cao-et-al-2006-increased-p53-activity-does-not-accelerate-telomere-driven-ageing.pdf | 167,61 kB | Adobe PDF | Visualizar/Abrir Solicitar una copia |
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