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https://doi.org/10.1038/s41586-019-1112-8
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Título: | p38γ is essential for cell cycle progression and liver tumorigenesis |
Fecha de publicación: | abr-2019 |
Editorial: | Nature Research |
Cita bibliográfica: | Nature 568(7753):557-560, 2019 |
ISSN: | Print: 0028-0836 Electrónico: 1476-4687 |
Materias relacionadas: | CDU::5 - Ciencias puras y naturales::57 - Ciencias biológicas en general:577 - 577 Bioquímica. Biología molecular. Biofísica |
Palabras clave: | p38γ |
Resumen: | The cell cycle is a tightly regulated process that is controlled by the conserved cyclin-dependent kinase (CDK)-cyclin protein complex1. However, control of the G0-to-G1 transition is not completely understood. Here we demonstrate that p38 MAPK gamma (p38γ) acts as a CDK-like kinase and thus cooperates with CDKs, regulating entry into the cell cycle. p38γ shares high sequence homology, inhibition sensitivity and substrate specificity with CDK family members. In mouse hepatocytes, p38γ induces proliferation after partial hepatectomy by promoting the phosphorylation of retinoblastoma tumour suppressor protein at known CDK target residues. Lack of p38γ or treatment with the p38γ inhibitor pirfenidone protects against the chemically induced formation of liver tumours. Furthermore, biopsies of human hepatocellular carcinoma show high expression of p38γ, suggesting that p38γ could be a therapeutic target in the treatment of this disease. |
Autor/es principal/es: | Tomas-Loba, Antonia Manieri, Elisa Gonzalez-Teran, Barbara Mora, Alfonso Leiva-Vega, Luis Santamans, Ayelen M Romero-Becerra, Rafael Rodriguez, Elena Pintor-Chocano, Aranzazu Feixas, Ferran Lopez, Juan Antonio Caballero, Beatriz Trakala, Marianna Blanco, Oscar Torres, Jorge L Hernandez-Cosido, Lourdes Montalvo-Romeral, Valle Matesanz, Nuria Roche-Molina, Marta Bernal, Juan Antonio Mischo, Hannah Leon, Marta Caballero, Ainoa Miranda-Saavedra, Diego Ruiz-Cabello, Jesus Nevzorova, Yulia A Cubero, Francisco Javier Bravo, Jeronimo Vazquez, Jesus Malumbres, Marcos Marcos, Miguel Osuna, Silvia Sabio, Guadalupe |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Departamento de Fisiología |
URI: | http://hdl.handle.net/10201/138771 |
DOI: | https://doi.org/10.1038/s41586-019-1112-8 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 27 |
Derechos: | info:eu-repo/semantics/openAccess |
Descripción: | ©<2019>. This manuscript version is made available under the CC-BY license http://creativecommons.org/licenses/by/4.0/ This document is the Acepted version of a Published Work that appeared in final form in [Molecular Cell]. To access the final edited and published work see [https://doi.org/10.1038/s41586-019-1112-8] |
Aparece en las colecciones: | Artículos: Fisiología |
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