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https://doi.org/10.1111/tbed.13354
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Título: | Serum proteome of dogs at subclinical and clinical onset of canine leishmaniosis |
Fecha de publicación: | 2019 |
Editorial: | Wiley-VCH |
Cita bibliográfica: | Transboundary and Emerging Diseases 67(1): 318-327 (2020) |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::63 - Agricultura. Silvicultura. Zootecnia. Caza. Pesca::636 - Veterinaria. Explotación y cría de animales. Cría del ganado y de animales domésticos |
Palabras clave: | Biomarkers Dog diseases, Leishmania, proteomics SWATH‐MS |
Resumen: | The objective of this study was to identify changes in serum proteome in dogs that may occur after an experimental infection at subclinical and clinical stages of canine leishmaniosis (CanL). For this purpose, canine pre- and post-infection with Leishmania infantum serum proteomes in the same dogs were analysed by a high-throughput label-based quantitative LC-MS/MS proteomic approach. A total of 169 proteins were identified, and 74 of them including complement C8 alpha chain, adiponectin, transferrin, sphingomyelin phosphodiesterase acid-like 3A and immunoglobulins showed different modulation between the different stages of CanL. These proteins could be considered as potential serum biomarkers of early diagnostic or disease progression in CanL. Additionally, biological pathways modulated during CanL such as blood coagulation or gonadotropin-releasing hormone receptor were revealed, which could help to understand the pathological mechanisms of the disease. |
Autor/es principal/es: | Franco-Martinez, Lorena Villar, Margarita Tvarijonaviciute, Asta Escribano, Damian Bernal, Luis J. Ceron, Jose J. Thomas, Maria del Carmen Mateos-Hernandez, Lourdes Tecles, Fernando De la Fuente, Jose López, Manuel C. Martinez-Subiela, Silvia |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Medicina y Cirugía Animal |
Versión del editor: | https://onlinelibrary.wiley.com/doi/10.1111/tbed.13354 |
URI: | http://hdl.handle.net/10201/138689 |
DOI: | https://doi.org/10.1111/tbed.13354 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 10 |
Derechos: | info:eu-repo/semantics/embargoedAccess |
Aparece en las colecciones: | Artículos: Medicina y Cirugía Animal |
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Transbounding Emerging Dis - 2019 - Franco‐Martínez - Serum proteome of dogs at subclinical and clinical onset of canine.pdf | 829,45 kB | Adobe PDF | Visualizar/Abrir Solicitar una copia |
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