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http://hdl.handle.net/10201/138429
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Título: | Human root dentin microhardness and degradation by triple antibiotic paste and calcium hydroxide |
Fecha de publicación: | 2022 |
Cita bibliográfica: | American Journal of Dentistry. 2022 35(4):205-211. |
ISSN: | 0894-8275 |
Palabras clave: | Triple antibiotic paste Calcium hydroxide Raman spectroscopy |
Resumen: | Purpose: To investigate and compare the effects of the two widely used regenerative endodontics medicaments: Triple antibiotic paste (ciprofloxacine-metronidazole-clindamycin) and calcium hydroxide on the microhardness and degradation of human root dentin. Methods: Following ethical approval and subject consent to use teeth in this research study, 60 singled-rooted permanent human teeth were randomly divided into six groups:(1) Tri-antibiotic paste with distilled water, or with (2) propylene glycol, (3) calcium hydroxide with distilled water, (4) calcium hydroxide propylene glycol, (5) untreated extracted teeth as negative controls, or (6) teeth instrumented and filled with calcium hydroxide or tri-antibiotic paste as positive controls. The microhardness tests were conducted after 1 and 2 months of exposure to the medicaments using a Vickers microhardness tester. Raman spectroscopy and energy dispersive x-ray spectroscopy were used to evaluate the chemistry and structure of the root dentin. Results: There were differences in the dentin microhardness following treatment with the medicaments or controls (P< 0.05). The time of root dentin exposure to the medicaments was similar (P> 0.05). The root dentin microhardness was lower in the teeth treated with the triple antibiotic paste or calcium hydroxide when combined with propylene glycol. The root dentin collagen in these treated teeth were also significantly degraded when viewed with Raman spectroscopy and energy dispersive x-ray spectroscopy, whereas the inorganic phase (dentin) remained unaltered. Samples exposed to the antimicrobial agents with water as a vehicle exhibited stronger microhardness and less degradation. |
Autor/es principal/es: | Guzmán, Sonia Caccia, Mario Cortés, Olga Bolarían, José M. Requena, Alberto García-Godoy, Alexander Boj, Juan R. García-Godoy, Franklin |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Dermatología, Estomatología, Radiología y Medicina Física |
URI: | http://hdl.handle.net/10201/138429 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 6 |
Derechos: | info:eu-repo/semantics/embargoedAccess |
Aparece en las colecciones: | Artículos: Dermatología, Estomatología, Radiología y Medicina Física |
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Guzman AJD August 2022 (1).pdf | 3,43 MB | Adobe PDF | ![]() Visualizar/Abrir Solicitar una copia |
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