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Título: | New insights into the pathophysiology of fasciculations in amyotrophic lateral sclerosis: an ultrasound study |
Fecha de publicación: | 2018 |
Editorial: | Elsevier |
Cita bibliográfica: | Clinical Neurophysiology 129 (2018) 2650–2657 |
ISSN: | 1388-2457 1872-8952 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::612 - Fisiología |
Palabras clave: | Amyotrophic lateral sclerosis Fasciculations Ultrasound Hyperexcitability Pathophysiology |
Resumen: | Objective: To describe the fasciculation pattern in ALS and to analyse its clinical and pathophysiological significance. Methods: Ultrasound of 19 muscles was performed in 44 patients with a recent diagnosis (<90 days) of ALS. The numberof fasciculationswas recorded in each muscle and the muscle thickness and strengthwere additionally measured in limb muscles. A subgroup of patients were electromyographically assessed. Results: US was performed in 835 muscles and EMG was available in 263 muscles. US detected fasciculations more frequently than EMG. Fasciculations were widespread, especially in upper limbs onset patients and in the cervical region. Fasciculations’ number inversely associated with ALSFR-R and body mass index (BMI) and directly with BMI loss and upper motor neuron (UMN) impairment. Our statistical model suggest that fasciculations increasewith the initial lower motor neuron (LMN) degeneration, reach their peak when the muscle became mildly to moderately weak, decreasing afterwards with increasing muscle weakness and atrophy. |
Autor/es principal/es: | Vázquez Costa, J. F. Campins Romeu, M. Martínez Payá, Jacinto Javier Tembl, J. I. Baño Aledo, María Elena del Ríos Díaz, J. Fornés Ferrer, V. Chumillas, M. J. Sevilla, T. |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Fisioterapia |
URI: | http://hdl.handle.net/10201/138292 |
DOI: | https://doi.org/10.1016/j.clinph.2018.09.014 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 8 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Descripción: | ©<2018>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Published Manuscript version of a Published Work that appeared in final form in [Clinical Neurophysiology]. To access the final edited and published work see [https://doi.org/10.1016/j.clinph.2018.09.014] |
Aparece en las colecciones: | Artículos: Fisioterapia |
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