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10.1111/ppe.12826
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Título: | The Nutrition in Early Life and Asthma (NELA) birth cohort study: Rationale, design, and methods |
Fecha de publicación: | 2022 |
Cita bibliográfica: | Paediatr Perinat Epidemiol. 2022 Mar;36(2):310-324. |
Palabras clave: | Allergy Asthma Diet Mother-child cohort Wheezing |
Resumen: | Background: Primary prevention strategies for asthma are lacking. Its inception probably starts in utero and/or during the early postnatal period as the developmental origins of health and disease (DOHaD) paradigm suggests. Objectives: The main objective of Nutrition in Early Life and Asthma (NELA) cohort study is to unravel whether the following factors contribute causally to the developmental origins of asthma: (1) maternal obesity/adiposity and foetal growth; (2) maternal and child nutrition; (3) outdoor air pollution; (4) endocrine disruptors; and (5) maternal psychological stress. Maternal and offspring biological samples are used to assess changes in offspring microbiome, immune system, epigenome and volatilome as potential mechanisms influencing disease susceptibility. Population: Randomly selected pregnant women from three health areas of Murcia, a south-eastern Mediterranean region of Spain, who fulfilled the inclusion criteria were invited to participate at the time of the follow-up visit for routine foetal anatomy scan at 19–22 weeks of gestation, at the Maternal-Fetal Medicine Unit of the “Virgen de la Arrixaca” University Clinical Hospital over a 36-month period, from March 2015 to April 2018. Design: Prospective, population-based, maternal-child, birth cohort study. Methods: Questionnaires on exposures and outcome variables were administered to mothers at 20–24 gestation week; 32–36 gestation week; and delivery. Children were surveyed at birth, 3 and 18 months of age and currently at 5 years. Furthermore, physical examinations were performed; and different measurements and biological samples were obtained at these time points. Preliminary results: Among the 1350 women invited to participate, 738 (54%) were finally enrolled in the study and 720 of their children were eligible at birth. The adherence was high with 612 children (83%) attending the 3 months’ visit and 532 children (72%) attending the 18 months’ visit. Conclusion: The NELA cohort will add original and unique knowledge to the developmental origins of asthma. |
Autor/es principal/es: | Morales, Eva Alcantara-Lopez, Maria V. Cabezas-Herrera, Juan Diego, Teresa de Hernandez-Caselles, Trinidad Jimenez-Guerrero, Pedro Larqué, Elvira Lopez-Soler, Concepción Martinez-Gracia, Carmen Martinez-Torres, Antonela Martin-Orozco, Elena Mendiola, Jaime Nieto-Díaz, Aníbal Noguera, Jose A. Perez-Fernandez, Virginia Prieto-Sánchez, M. Teresa Salvador-Garcia, Carme Sanchez-Solis, Manuel Santaella-Pascual, Marina Sola-Martinez, Rosa A. Torres-Cantero, Alberto Yagüe-Guirao, Genoveva Zornoza-Moreno, Matilde García-Marcos, Luis |
URI: | http://hdl.handle.net/10201/138240 |
DOI: | 10.1111/ppe.12826 |
Tipo de documento: | info:eu-repo/semantics/article |
Derechos: | info:eu-repo/semantics/embargoAccess |
Descripción: | Acceso restringido |
Aparece en las colecciones: | Artículos: Ciencias Sociosanitarias |
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Fichero | Descripción | Tamaño | Formato | |
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73- Morales- PPE 2022.pdf | 720,72 kB | Adobe PDF | Visualizar/Abrir Solicitar una copia |
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