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Título: | An Upgrade on the Rabbit Model of Anthracycline-Induced Cardiomyopathy: Shorter Protocol, Reduced Mortality, and Higher Incidence of Overt Dilated Cardiomyopathy |
Fecha de publicación: | 1-dic-2015 |
ISSN: | Print 2314-6133 Electronic 2314-6141 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Resumen: | Current protocols of anthracycline-induced cardiomyopathy in rabbits present with high premature mortality and nephrotoxicity, thus rendering them unsuitable for studies requiring long-term functional evaluation of myocardial function (e.g., stem cell therapy). We compared two previously described protocols to an in-house developed protocol in three groups: Group DOX2 received doxorubicin 2 mg/kg/week (8 weeks); Group DAU3 received daunorubicin 3 mg/kg/week (10 weeks); and Group DAU4 received daunorubicin 4mg/kg/week (6 weeks). A cohort of rabbits received saline (control). Results of blood tests, cardiac troponin I, echocardiography, and histopathology were analysed. Whilst DOX2 and DAU3 rabbits showed high premature mortality (50% and 33%, resp.), DAU4 rabbits showed 7.6% premature mortality. None of DOX2 rabbits developed overt dilated cardiomyopathy; 66% of DAU3 rabbits developed overt dilated cardiomyopathy and quickly progressed to severe congestive heart failure. Interestingly, 92% of DAU4 rabbits showed overt dilated cardiomyopathy and 67% developed congestive heart failure exhibiting stable disease. DOX2 and DAU3 rabbits showed alterations of renal function, with DAU3 also exhibiting hepatic function compromise. Thus, a shortened protocol of anthracycline-induced cardiomyopathy as in DAU4 group results in high incidence of overt dilated cardiomyopathy, which insidiously progressed to congestive heart failure, associated to reduced systemic compromise and very low premature mortality. |
Autor/es principal/es: | Talavera López, Jesús Giraldo, Alejandro Fernández del Palacio, María Josefa García-Nicolás, Obdulio Seva, Juan Brooks, Gavin Moraleda, Jose María |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Medicina y Cirugía Animal |
URI: | http://hdl.handle.net/10201/137937 |
DOI: | http://dx.doi.org/10.1155/2015/465342 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 14 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Descripción: | Copyright © 2015 Jesus Talavera et al. This is an open access article distributed under the Creative Commons Attribution License, ´ which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Matería temporal: | 2015 |
Matería geográfica: | España |
Aparece en las colecciones: | Artículos: Medicina y Cirugía Animal |
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PDF DEFINITIVO PUBLICADO BRMI.pdf | 4,78 MB | Adobe PDF | Visualizar/Abrir |
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