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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Soto, Teresa | - |
dc.contributor.author | Núñez, Andrés | - |
dc.contributor.author | Madrid, Marisa | - |
dc.contributor.author | Vicente, Jero | - |
dc.contributor.author | Gacto, Mariano | - |
dc.contributor.author | Cansado, José | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Genética y Microbiología | es |
dc.date.accessioned | 2024-01-29T11:33:16Z | - |
dc.date.available | 2024-01-29T11:33:16Z | - |
dc.date.issued | 2007-05-01 | - |
dc.identifier.citation | Microbiology. Vol153(5):1519-1529. 2007 | es |
dc.identifier.issn | 1465-2080 Electronic | - |
dc.identifier.issn | 1350-0872 Print | - |
dc.identifier.uri | http://hdl.handle.net/10201/137933 | - |
dc.description | ©<2007>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Published Manuscript version of a Published Work that appeared in final form in [Microbiology]. To access the final edited and published work see [https://doi.org/10.1099/mic.0.2006/004283-0] | es |
dc.description.abstract | Centrifugation of cells of Schizosaccharomyces pombe in liquid medium prompted a marked activation of Sty1 and Pmk1, which are the effector mitogen-activated protein kinases (MAPKs) of the stress-activated protein kinase pathway and the cell-integrity pathway, respectively. Transduction of the centrifugation signals showed a sensitivity threshold above which the response was dependent on time and temperature. Centrifugation-induced phosphorylation of Sty1 and Pmk1 required the presence of the main functional components of the respective signalling cascades, i.e. Wak1 or Win1 plus Wis1, and Mkh1 plus Pek1. The transcription factor Atf1 also became phosphorylated in a Sty1-dependent way upon centrifugation. Hypergravity was an important factor in the activation of Sty1 induced by centrifugation, whilst activation of Pmk1 was mostly due to gravity-associated shear forces. Centrifugation did not increase cell survival against other stresses. Rather, the increased gravitational forces produced a delay in the cell cycle, probably related to alterations in the actin-polarization pattern. Phosphorylation of the MAPK Sty1 was needed for the depolarization of actin patches induced by the centrifugation stress. | es |
dc.format | application/pdf | es |
dc.format.extent | 11 | es |
dc.language | eng | es |
dc.publisher | Microbiology Society | es |
dc.relation | Ámbito del proyecto: Nacional. Agencia financiadora: Ministerio de Educación y Ciencia Convocatoria:2005 Nombre del proyecto: Dianas celulares y mecanismos de control del crecimiento regulados por la MAPK Spm1 en S. pombe. Caracterización de los circuitos moleculares que definen su activación Código o número del acuerdo de subvención: BFU200501401/BMC. Ámbito del proyecto: Regional. Agencia financiadora: Fundación Séneca (Región de Murcia). Convocatoria: 2004. Nombre del proyecto: Estudio sobre la activación por estrés de la ruta de mapa de integridad celular en Schizosaccharomyces pombe Código o número del acuerdo de subvención: 00475/PI/04. | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Mitogen-activated protein kinase | es |
dc.subject | MAP quinasa | es |
dc.subject | Fission yeast | es |
dc.subject | Microbiology | es |
dc.subject | Centrifugation | es |
dc.subject | Cell signalling | es |
dc.subject.other | CDU::5 - Ciencias puras y naturales::57 - Biología::579 - Microbiología | es |
dc.subject.other | CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología | es |
dc.subject.other | CDU::5 - Ciencias puras y naturales::57 - Biología::577 - Bioquímica. Biología molecular. Biofísica | es |
dc.title | Transduction of centrifugation-induced gravity forces through mitogen-activated protein kinase pathways in the fission yeast Schizosaccharomyces pombe | es |
dc.type | info:eu-repo/semantics/article | es |
dc.relation.publisherversion | https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.2006/004283-0 | es |
dc.identifier.doi | https://doi.org/10.1099/mic.0.2006/004283-0 | - |
Aparece en las colecciones: | Artículos: Genética y Microbiología |
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