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10.3390/antiox9010085
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Giménez-Siurana, Ana | - |
dc.contributor.author | Gomez Garcia, Francisco | - |
dc.contributor.author | Pagan Bernabeu, Ana | - |
dc.contributor.author | Lozano-Pérez, Abel | - |
dc.contributor.author | Aznar-Cervantes, Salvador | - |
dc.contributor.author | Cenis, Luis | - |
dc.contributor.author | Lopez Jornet, Pia | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Dermatología, Estomatología, Radiología y Medicina Física | es |
dc.date.accessioned | 2024-01-25T12:32:13Z | - |
dc.date.available | 2024-01-25T12:32:13Z | - |
dc.date.issued | 2020-01-19 | - |
dc.identifier.citation | Antioxidants Volume 9 Issue 1 10.3390/antiox9010085 | es |
dc.identifier.issn | Electronic: 2076-3921 | - |
dc.identifier.uri | http://hdl.handle.net/10201/137745 | - |
dc.description | ©2020. The authors. This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the accepted version of a published work that appeared in final form in Antioxidants. | es |
dc.description.abstract | Objective: the objective of the present work is to study the e ectiveness of treatment with silk fibroin nanoparticles loaded with resveratrol in experimental periodontitis in a diabetic rat model. Introduction: Periodontitis is an inflammatory pathology highly related to other diseases, such as type II diabetes. Both diseases have a specific inflammatory condition, with Interleukin (IL)-6, IL-1 and Transforming Grow Factor (TGF)-1 being the most relevant proinflammatory factors. Silk fibroin (SF) nanoparticles loaded with resveratrol (Res-SFN) are a new alternative as a treatment. Methods: 40 diabetic Sprague Dawley male rats were used and periodontitis was induced by ligation. The animals were divided into 5 treatment groups, and 1 mL of treatment was administered once a day for 4 weeks. The groups were: I: Carboxymethyl cellulose (CMC) 0.8%, II: CMC 0.8% + SF 1%, III: CMC 0.8% + RES-SFN 3 mg/mL, IV: CMC 0.8% + SF 1% + RES-SFN 3 mg/mL, V: Water. A peripheral blood sample was taken every week to quantify the inflammatory profile by ELISA (IL-6, IL-1 and TGF-1 ). After 4 weeks the sacrifice was carried out and biopsies of the gum were taken. Results: Treatment with SF and RES-SFN reduced the amount of chemical inflammation mediators (with the exception of IL-1 in comparisons I-IV and II-IV (p > 0.05)), as well as the anatomopathological variables linked to it, in a significant way (p < 0.05). Conclusion: treatment with RES-SFN has reduced local inflammation in this experimental periodontitis model | es |
dc.format | application/pdf | es |
dc.format.extent | 13 | es |
dc.language | eng | es |
dc.publisher | MDPI | es |
dc.relation | Sin financion externa | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Resveratrol | es |
dc.subject | Periodontitis | es |
dc.subject | Silk fibroin nanoparticles | es |
dc.subject | Inflammation | es |
dc.subject | IL-6 | es |
dc.subject | IL-1 | es |
dc.subject | TGF-1 | es |
dc.subject | Diabetes | es |
dc.title | Chemoprevention of Experimental Periodontitis in Diabetic Rats with Silk Fibroin Nanoparticles Loaded with Resveratrol | es |
dc.type | info:eu-repo/semantics/article | es |
dc.relation.publisherversion | https://www.mdpi.com/2076-3921/9/1/85 | es |
dc.identifier.doi | 10.3390/antiox9010085 | - |
Aparece en las colecciones: | Artículos: Dermatología, Estomatología, Radiología y Medicina Física |
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antioxidants-09-00085.pdf | 1,55 MB | Adobe PDF | Visualizar/Abrir |
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