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10.1016/j.immuni.2012.06.013
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Compan, Vincent | - |
dc.contributor.author | Baroja-Mazo, Alberto | - |
dc.contributor.author | Lopez-Castejón, Gloria | - |
dc.contributor.author | Gomez, Ana I. | - |
dc.contributor.author | Martínez, Carlos M. | - |
dc.contributor.author | Angosto, Diego | - |
dc.contributor.author | Montero, María T. | - |
dc.contributor.author | Herranz, Antonio S. | - |
dc.contributor.author | Bazán, Eulalia | - |
dc.contributor.author | Reimers, Diana | - |
dc.contributor.author | Mulero, Victoriano | - |
dc.contributor.author | Pelegrín Vivancos, Pablo | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Bioquímica y Biología Molecular B e Inmunología | es |
dc.date.accessioned | 2024-01-25T09:42:05Z | - |
dc.date.available | 2024-01-25T09:42:05Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Immunity, volumen 37, nº 3, año 2012, páginas 487-500. | es |
dc.identifier.issn | 1097-4180 | - |
dc.identifier.issn | 1074-7613 | - |
dc.identifier.uri | http://hdl.handle.net/10201/137738 | - |
dc.description | ©2012. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted version of a Published Work that appeared in final form in Immunity. To access the final edited and published work see https://doi.org/10.1016/j.immuni.2012.06.013 | es |
dc.description.abstract | Cell volume regulation is a primitive response to alterations in environmental osmolarity. The NLRP3 inflammasome is a multiprotein complex that senses pathogen- and danger-associated signals. Here we report that the basic mechanisms of cell swelling and regulatory volume decrease (RVD) are sensed from fish to mammals by the NLRP3 inflammasome. We found that a decrease in extracellular osmolarity induced (i) a K+-dependent conformational change of the preassembled NLRP3-inactive inflammasome during cell swelling, followed by (ii) activation of the NLRP3 inflammasome and caspase-1, which was controlled by Transient Receptor Potential (TRP) channels during RVD. Both mechanisms were necessary for interleukin-1b processing. Increased extracellular osmolarity prevented caspase-1 activation by different known NLRP3 activators. Collectively, our data place cell volume regulation as a basic conserved homeostatic mechanism associated with the formation of the NLRP3 inflammasome and provides a mechanism for NLRP3 inflammasome activation. | es |
dc.format | application/pdf | es |
dc.format.extent | 45 | es |
dc.language | eng | es |
dc.publisher | Cell Press | es |
dc.relation | Wellcome Trust, PN I+D+I 2008-2011-Instituto Salud Carlos III-FEDER (EMER07/049 y PI09/0120), Fundación Séneca (11922/PI/09), Spanish Ministry of Science and Technology (BIO2008-01379, BIO2011-23400) y Fundación Marcelino Botín. | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | TRP channels | es |
dc.subject | Volumen celular | es |
dc.subject | Inflamasoma | es |
dc.subject | macrófagos | es |
dc.subject | Citocinas | es |
dc.subject | Inflamación | es |
dc.subject.other | CDU::6 - Ciencias aplicadas | es |
dc.title | Cell volume regulation modulates NLRP3 inflammasome activation | es |
dc.type | info:eu-repo/semantics/article | es |
dc.relation.publisherversion | https://www.cell.com/immunity/fulltext/S1074-7613(12)00373-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761312003731%3Fshowall%3Dtrue | es |
dc.identifier.doi | 10.1016/j.immuni.2012.06.013 | - |
Aparece en las colecciones: | Artículos: Bioquímica y Biología Molecular "B" e Inmunología |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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IMMUNITY-D-11-00538R2_Main text.pdf | Versión aceptada del artículo | 10 MB | Adobe PDF | Visualizar/Abrir |
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