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10.1038/sj.emboj.7601378
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Pelegrin, Pablo | - |
dc.contributor.author | Surprenant, Annmarie | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Bioquímica y Biología Molecular B e Inmunología | es |
dc.date.accessioned | 2024-01-24T17:22:04Z | - |
dc.date.available | 2024-01-24T17:22:04Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | EMBO Journal, volumen 25, nº 21, año 2006, páginas: 5071-5082. | es |
dc.identifier.issn | 0261-4189 | - |
dc.identifier.issn | 1460-2075 | - |
dc.identifier.uri | http://hdl.handle.net/10201/137719 | - |
dc.description | ©2006. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the, Accepted, version of a Published Work that appeared in final form in The EMBO Journal. To access the final edited and published work see https://doi.org/10.1038/sj.emboj.7601378 | es |
dc.description.abstract | P2X(7) receptors are ATP-gated cation channels; their activation in macrophage also leads to rapid opening of a membrane pore permeable to dyes such as ethidium, and to release of the pro-inflammatory cytokine, interleukin-1beta (IL-1beta). It has not been known what this dye-uptake path is, or whether it is involved in downstream signalling to IL-1beta release. Here, we identify pannexin-1, a recently described mammalian protein that functions as a hemichannel when ectopically expressed, as this dye-uptake pathway and show that signalling through pannexin-1 is required for processing of caspase-1 and release of mature IL-1beta induced by P2X(7) receptor activation. | es |
dc.format | application/pdf | es |
dc.format.extent | 45 | es |
dc.language | eng | es |
dc.relation | Wellcome Trust y AstraZeneca Charnwood. | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Citocinas | es |
dc.subject | Canal iónico | es |
dc.subject | Hemicanal | es |
dc.subject | Inflamasoma | es |
dc.subject | Receptor purinérgico | es |
dc.subject.other | CDU::6 - Ciencias aplicadas | es |
dc.title | Pannexin-1 mediates large pore formation and interleukin-1ß release by the ATP-gated P2X7 receptor | es |
dc.type | info:eu-repo/semantics/article | es |
dc.relation.publisherversion | https://www.embopress.org/doi/full/10.1038/sj.emboj.7601378?pubCode=cgi | es |
dc.identifier.doi | 10.1038/sj.emboj.7601378 | - |
Aparece en las colecciones: | Artículos: Bioquímica y Biología Molecular "B" e Inmunología |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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2006 EMBO J Panx.pdf | Versión de artículo aceptado | 5 MB | Adobe PDF | Visualizar/Abrir |
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