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https://doi.org/10.3390/nu10040484
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Título: | Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats |
Fecha de publicación: | 13-abr-2018 |
Editorial: | MDPI |
Cita bibliográfica: | Nutrients 2018, 10, 484; |
ISSN: | Electronic: 2072-6643 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::612 - Fisiología |
Palabras clave: | Flavonoides Hipertensión arterial Óxido nítrico Flavonoids Nitric oxide Heart; kidney Sodium balance Phenylephrine Acetylcholine |
Resumen: | Background: we have evaluated the antihypertensive effect of several flavonoid extracts in a rat model of arterial hypertension caused by chronic administration (6 weeks) of the nitric oxide synthesis inhibitor, L-NAME. Methods: Sprague Dawley rats received L-NAME alone or L-NAME plus flavonoid-rich vegetal extracts (Lemon, Grapefruit + Bitter Orange, and Cocoa) or purified flavonoids (Apigenin and Diosmin) for 6 weeks. Results: L-NAME treatment resulted in a marked elevation of blood pressure, and treatment with Apigenin, Lemon Extract, and Grapefruit + Bitter Orange extracts significantly reduced the elevated blood pressure of these animals. Apigenin and some of these flavonoids also ameliorated nitric oxide-dependent and -independent aortic vasodilation and elevated nitrite urinary excretion. End-organ abnormalities such as cardiac infarcts, hyaline arteriopathy and fibrinoid necrosis in coronary arteries and aorta were improved by these treatments, reducing the end-organ vascular damage. Conclusions: the flavonoids included in this study, specially apigenin, may be used as functional food ingredients with potential therapeutic benefit in arterial hypertension |
Autor/es principal/es: | Paredes, María Dolores Romecín, Paola Atucha, Noemí. M. O'Valle, Francisco Castillo, Julián Ortiz, M. Clara García-Estañ, Joaquín |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Fisiología |
Versión del editor: | https://www.mdpi.com/2072-6643/10/4/484 |
URI: | http://hdl.handle.net/10201/137622 |
DOI: | https://doi.org/10.3390/nu10040484 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 15 |
Derechos: | info:eu-repo/semantics/openAccess Atribución 4.0 Internacional |
Descripción: | © 2018. The authors. This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the published version of a published work that appeared in final form in Nutrients |
Aparece en las colecciones: | Artículos: Fisiología |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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nutrients-10-00484.pdf | Paper flavonoides en hipertensión L-NAME | 3,56 MB | Adobe PDF | Visualizar/Abrir |
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