Por favor, use este identificador para citar o enlazar este ítem: https://doi.org/10.14670/HH-18-659

Título: Extracellular vesicles in acute respiratory distress syndrome: Understanding protective and harmful signaling for the development of new therapeutics
Fecha de publicación: 2024
Editorial: Universidad de Murcia. Departamento de Biología Celular e Histología
Cita bibliográfica: Histology and Histopathology, Vol.39, nº2, (2024)
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología
Palabras clave: Acute respiratory distress syndrome (ARDS)
Acute Lung Injury (ALI)
Extracellular vesicles (EVs)
Alveolo-capillary permeability
Therapeutics, EVs biogenesis
EVs internalization
Resumen: Acute respiratory distress syndrome (ARDS) is a severe respiratory condition characterized by increased lung permeability, hyper-inflammatory state, and fluid leak into the alveolar spaces. ARDS is a heterogeneous disease, with multiple direct and indirect causes that result in a mortality of up to 40%. Due to the ongoing Covid-19 pandemic, its incidence has increased up to ten-fold. Extracellular vesicles (EVs) are small liposome-like particles that mediate intercellular communication and play a major role in ARDS pathophysiology. Indeed, they participate in endothelial barrier dysfunction and permeability, neutrophil, and macrophage activation, and also in the development of a hypercoagulable state. A more thorough understanding of the variegated and cell-specific functions of EVs may lead to the development of safe and effective therapeutics. In this review, we have collected evidence of EVs role in ARDS, revise the main mechanisms of production and internalization and summarize the current therapeutical approaches that have shown the ability to modulate EV signaling.
Autor/es principal/es: Bavuso, Matthew
Miller, Noel
Sill, Joshua M.
Dobrian, Anca
Colunga Biancatelli, Ruben M.L.
URI: http://hdl.handle.net/10201/137598
DOI: https://doi.org/10.14670/HH-18-659
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 14
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.39, nº2 (2024)

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