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Título: | Aminopeptidases in Cardiovascular and Renal Function. Role as Predictive Renal Injury Biomarkers |
Fecha de publicación: | 5-ago-2020 |
Editorial: | MDPI |
Cita bibliográfica: | International Journal of Molecular Sciences 2020, 21, 5615; |
ISSN: | Print: 1661-6596 Electronic: 1422-0067 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::612 - Fisiología |
Palabras clave: | Aminopeptidasas Función Renal Urinary aminopeptidases Aiomarkers Arterial hypertension Renal function |
Resumen: | Aminopeptidases (APs) are metalloenzymes that hydrolyze peptides and polypeptides by scission of the N-terminus amino acid and that also participate in the intracellular final digestion of proteins. APs play an important role in protein maturation, signal transduction, and cell-cycle control, among other processes. These enzymes are especially relevant in the control of cardiovascular and renal functions. APs participate in the regulation of the systemic and local renin–angiotensin system and also modulate the activity of neuropeptides, kinins, immunomodulatory peptides, and cytokines, even contributing to cholesterol uptake and angiogenesis. This review focuses on the role of four key APs, aspartyl-, alanyl-, glutamyl-, and leucyl-cystinyl-aminopeptidases, in the control of blood pressure (BP) and renal function and on their association with different cardiovascular and renal diseases. In this context, the effects of AP inhibitors are analyzed as therapeutic tools for BP control and renal diseases. Their role as urinary biomarkers of renal injury is also explored. The enzymatic activities of urinary APs, which act as hydrolyzing peptides on the luminal surface of the renal tubule, have emerged as early predictive renal injury biomarkers in both acute and chronic renal nephropathies, including those induced by nephrotoxic agents, obesity, hypertension, or diabetes. Hence, the analysis of urinary AP appears to be a promising diagnostic and prognostic approach to renal disease in both research and clinical settings. |
Autor/es principal/es: | Vargas, Félix Wangesteen, Rosemary Rodríguez-Gómez, Isabel García-Estañ, Joaquín |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Fisiología |
URI: | http://hdl.handle.net/10201/137595 |
DOI: | https://doi.org/10.3390/ijms21165615 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 20 |
Derechos: | info:eu-repo/semantics/openAccess Atribución 4.0 Internacional |
Descripción: | © 2023. The authors. This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the published version of a published work that appeared in final form in International Journal of Molecular Sciences |
Aparece en las colecciones: | Artículos: Fisiología |
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Fichero | Descripción | Tamaño | Formato | |
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ijms-21-05615.pdf | Paper aminopeptidasas y funicón renal | 1,72 MB | Adobe PDF | Visualizar/Abrir |
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