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10.1016/j.jacbts.2019.07.010
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Iborra Egea, Oriol | - |
dc.contributor.author | Santiago Vacas, Evelyn | - |
dc.contributor.author | Yurista, Salva | - |
dc.contributor.author | Lupon, Josep | - |
dc.contributor.author | Packer, Milton | - |
dc.contributor.author | Heymans, Stephane | - |
dc.contributor.author | Pascual Figal, Domingo A. | - |
dc.contributor.author | Lax Pérez, Antonio Manuel | - |
dc.contributor.author | Bayes Genis, Antoni | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Medicina | es |
dc.date.accessioned | 2024-01-23T12:31:46Z | - |
dc.date.available | 2024-01-23T12:31:46Z | - |
dc.date.issued | 2019-10 | - |
dc.identifier.citation | JACC Basic Transl Sci. 2019 Oct 23;4(7):831-840.doi: 10.1016/j.jacbts.2019.07.010. | es |
dc.identifier.uri | http://hdl.handle.net/10201/137594 | - |
dc.description.abstract | he mechanism of action of empagliflozin in heart failure with reduced ejection fraction (HFrEF) was deciphered using deep learning in silico analyses together with in vivo validation. The most robust mechanism of action involved the sodium-hydrogen exchanger (NHE)-1 co-transporter with 94.7% accuracy, which was similar for diabetics and nondiabetics. Notably, direct NHE1 blockade by empagliflozin ameliorated cardiomyocyte cell death by restoring expression of X-linked inhibitor of apoptosis (XIAP) and baculoviral IAP repeat-containing protein 5 (BIRC5). These results were independent of diabetes mellitus comorbidity, suggesting that empagliflozin may emerge as a new treatment in HFrEF. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 | es |
dc.language | eng | es |
dc.relation | Dr. Yurista is supported by Indonesia Endowment Fund for Education grant LPDP 20150722083422. | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Unraveling the Molecular Mechanism of Action of Empagliflozin in Heart Failure With Reduced Ejection Fraction With or Without Diabetes | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | 10.1016/j.jacbts.2019.07.010 | - |
Aparece en las colecciones: | Artículos: Medicina |
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Fichero | Descripción | Tamaño | Formato | |
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Unraveling the Molecular Mechanism of Action of Empagliflozin in Heart Failure With Reduced Ejection Fraction With or Without Diabete.pdf | 1,11 MB | Adobe PDF | Visualizar/Abrir | |
mmc1-5.pdf | 185,55 kB | Adobe PDF | Visualizar/Abrir |
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