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10.1007/s12265-017-9761-1
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Título: | Early Anti-inflammatory and Pro-angiogenic Myocardial Effects of Intravenous Serelaxin Infusion for 72 H in an Experimental Rat Model of Acute Myocardial Infarction |
Fecha de publicación: | dic-2017 |
Cita bibliográfica: | Journal of Cardiovascular Translational Research. 2017 Dec;10(5-6):460-469.doi: 10.1007/s12265-017-9761-1. |
ISSN: | 1937-5395 1937-5387 |
Palabras clave: | Myocardial infarction Left ventricular systolic dysfunction Serelaxin Remodeling Fibrosis |
Resumen: | Sprague Dawley rats were subjected to acute myocardial infarction (AMI) by permanent ligation of the left anterior descending coronary artery. At the time of AMI, a subcutaneous mini-osmotic pump was implanted and animals were randomized into three groups, according to the intravenous therapy received during the first 72 h: placebo-treated (saline), serelaxin10-treated (SRLX10 = 10 μg/kg/day), or serelaxin30-treated (SRLX30 = 30 μg/kg/day). Treatment with SRLX30 reduced the expression of inflammatory cytokines and chemokines, as well as the infiltration of macrophages, and increased the expression of pro-angiogenic markers and vessel density in the infarcted myocardium after 7 days. SRLX30 did not reduce early myocardial fibrosis but reduced myocardial levels of sST2 and galectin-3. No significant effects were observed with SRLX10 treatment. A significant correlation was observed between plasma levels of serelaxin and effect measures. The results suggest serelaxin has a protective effect in early processes of cardiac remodeling after AMI. |
Autor/es principal/es: | Sanchez Mas, Jesus Lax Pérez, Antonio Manuel Asensio Lopez, Maria del Carmen Fernandez del Palacio, Maria J de Boer, Rudolf Pascual Figal, Domingo A. |
Facultad/Departamentos/Servicios: | Medicina |
URI: | http://hdl.handle.net/10201/137592 |
DOI: | 10.1007/s12265-017-9761-1 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 10 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Descripción: | ©2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted version of a Published Work that appeared in final form in Journal of Cardiovascular Translational Research. To access the final edited and published work see https://doi.org/10.1007/s12265-017-9761-1 |
Aparece en las colecciones: | Artículos: Medicina |
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